Materials for diabetes therapeutics.
Materials for diabetes therapeutics.
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DOI：
10.1002/adhm.201200037
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发表时间：
2012-05
影响因子：
10
通讯作者：
Anderson, Daniel G.
中科院分区：
文献类型：
--
作者：
Bratlie, Kaitlin M.;York, Roger L.;Invernale, Michael A.;Langer, Robert;Anderson, Daniel G.
本文综述了用于1型糖尿病治疗的闭环系统的材料和方法。在此，我们简要概述了目前用于患者护理的方法，并讨论了两种可能的治疗方法和用于这些治疗的材料——(i)人工胰腺，由嵌入在聚合物生物材料中的胰岛素产生细胞组成；（ii）完全合成胰腺，通过可降解聚合物和葡萄糖反应聚合物系统集成连续血糖监测仪和控制胰岛素释放。人工胰腺和完全合成胰腺都有两个主要的设计要求：该装置必须具有生物相容性，并能渗透到小分子和蛋白质（如胰岛素）中。讨论了几种人造胰腺的聚合物和制备方法：微胶囊化、保形涂层和平面片。我们也回顾了完全合成胰腺的两个组成部分。几种类型的葡萄糖传感系统（包括用于电化学，光学和化学传感平台的材料）被讨论，除了各种聚合物为基础的释放系统（包括乙烯-醋酸乙烯，聚酸酐，和苯硼酸含有水凝胶）。
This review is focused on the materials and methods used to fabricate closed-loop systems for type 1 diabetes therapy. Herein, we give a brief overview of current methods used for patient care and discuss two types of possible treatments and the materials used for these therapies–(i) artificial pancreases, comprised of insulin producing cells embedded in a polymeric biomaterial, and (ii) totally synthetic pancreases formulated by integrating continuous glucose monitors with controlled insulin release through degradable polymers and glucose-responsive polymer systems. Both the artificial and the completely synthetic pancreas have two major design requirements: the device must be both biocompatible and be permeable to small molecules and proteins, such as insulin. Several polymers and fabrication methods of artificial pancreases are discussed: microencapsulation, conformal coatings, and planar sheets. We also review the two components of a completely synthetic pancreas. Several types of glucose sensing systems (including materials used for electrochemical, optical, and chemical sensing platforms) are discussed, in addition to various polymer-based release systems (including ethylene-vinyl acetate, polyanhydrides, and phenylboronic acid containing hydrogels).
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影响因子：
3.7
作者：
Cheng, JJ;Teply, BA;Langer, RS
通讯作者：
Langer, RS
影响因子：
3.8
作者：
Brown, LR;Edelman, ER;Langer, R
通讯作者：
Langer, R
影响因子：
4.1
作者：
COULTHARD, CE;MICHAELIS, R;BIRKINSHAW, JH
通讯作者：
BIRKINSHAW, JH
同质，非对称细胞水凝胶胶囊的微结构。
影响因子：
14
作者：
Dang TT;Xu Q;Bratlie KM;O'Sullivan ES;Chen XY;Langer R;Anderson DG
通讯作者：
Anderson DG
影响因子：
7.4
作者：
Barman, Ishan;Kong, Chae-Ryon;Singh, Gajendra P.;Dasari, Ramachandra R.;Feld, Michael S.
通讯作者：
Feld, Michael S.