An Atypical Case of Monomicrobial Clostridioides difficile Septicemia With No Gastrointestinal Manifestations.
An Atypical Case of Monomicrobial Clostridioides difficile Septicemia With No Gastrointestinal Manifestations.
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DOI：
10.3389/fcimb.2022.853252
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发表时间：
2022
影响因子：
5.7
通讯作者：
中科院分区：
文献类型：
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作者：
浙江中国报告1例罕见的单菌艰难梭状芽胞杆菌败血症。一旦确诊，万古霉素治疗就清除了感染。患者没有明显的病史，检查也没有明显的胃肠道症状，尽管在他的粪便样本中检测到艰难梭菌。然而，我们后来利用全基因组测序分析确定了从血液样本中分离的艰难梭菌与从其粪便中分离的艰难梭菌不同。通过对他的医疗记录的回顾分析，我们注意到这名男子最近拔牙，因此细菌可能已经通过根管入侵。因此，我们认为口腔艰难梭菌定植可能是严重艰难梭菌败血症的潜在危险因素，这在临床上可能是令人担忧的。
An uncommon case of monomicrobial Clostridioides difficile septicemia in a 63-year-old man was reported in Zhejiang, China. Once diagnosed, vancomycin treatment cleared the infections. The patient had no remarkable medical history, and the inspection showed no overt gastrointestinal symptoms, though C. difficile was detected in his stool samples. However, we later defined that the C. difficile strain isolated from the blood sample was different from the one isolated from his stool using the whole genome sequencing analysis. By retrospective analysis of his medical record, we noticed that the man had a recent tooth extraction thus the bacterium may have invaded through the root canal. Therefore, we suggest that oral C. difficile colonization may be a potential risk factor for severe C. difficile septicemia, which could be clinically alarming.
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开放式细菌种群基因组学：BIGSDB软件，pubmlst.org网站及其应用。
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作者：
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影响因子：
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作者：
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作者：
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