Malignancy is associated with dermatomyositis but not polymyositis in Northern New England, USA.
Malignancy is associated with dermatomyositis but not polymyositis in Northern New England, USA.
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DOI：
10.3899/jrheum.090549
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发表时间：
2009-12
期刊：
影响因子：
--
通讯作者：
Rigby WF
中科院分区：
文献类型：
--
作者：
Antiochos BB;Brown LA;Li Z;Tosteson TD;Wortmann RL;Rigby WF
回顾评估23年间在一个学术中心就诊的患者中特发性炎症性肌病(IIM)与恶性肿瘤之间的关系。患者使用国际疾病分类第9版(ICD-9)代码和诊断进行识别，然后通过图表检查进行确认。从佛蒙特州和新罕布夏州的美国疾病控制中心获得的人口癌症统计数据用于比较。图表回顾证实ICD-9编码最初确定的483名患者中有198名为IIM。在诊断为IIM的5年内，32例(16.2%)患者发生了恶性肿瘤，其中24例(75%)患有皮肌炎(DM)。75%的患者在1年内发展为恶性肿瘤和糖尿病。与糖尿病相关的癌症风险比与其他IIM相关的风险大得多。最常见的肿瘤类型是乳房、肺、胰腺和结肠。与非癌症患者相比，糖尿病合并癌症的患者更多的是男性，≥年龄在45岁。在癌症和任何形式的IIM患者中没有间质性肺疾病的病例。与年龄和性别匹配的人群对照组相比，糖尿病患者的癌症发病率增加，无论是在糖尿病诊断前后的5年时间间隔内，还是在诊断后的终身间隔时间内。IIM的癌症风险集中在糖尿病患者中。在87.5%的病例中，糖尿病和癌症之间的关联因其时间关系(1年)而增强。与恶性肿瘤相关的糖尿病患者多为男性，年龄在45岁以上，较少发生间质性肺部疾病。
To retrospectively evaluate the association of idiopathic inflammatory myopathy (IIM) and malignancy in patients seen at 1 academic center over a 23-year period. Patients were identified using the International Classification of Diseases, 9th edition (ICD-9) codes and diagnoses, then confirmed by chart review. Population cancer statistics obtained from the US Centers for Disease Control for Vermont and New Hampshire were used for comparison. Chart review confirmed IIM in 198 of 483 patients initially identified by ICD-9 codes. Within 5 years of diagnosis with IIM, malignancy developed in 32 patients (16.2%), 24 of whom (75%) had dermatomyositis (DM). Malignancy and DM developed within 1 year in 75%. The cancer risk associated with DM was much greater than the risk associated with other IIM. The most frequent tumor types were breast, lung, pancreas, and colon. DM patients with cancer were more frequently male and ≥ 45 years of age than those without cancer. There were no cases of interstitial lung disease among patients with cancer and any form of IIM. The incidence of cancer was increased in patients with DM compared to age- and sex-matched population controls, both over a 5-year interval surrounding the diagnosis of DM and over the lifetime interval following diagnosis. The risk of cancer in IIM is concentrated among patients with DM. The association between DM and cancer was enhanced by its temporal relationship (< 1 year) in 87.5% of these cases. Patients with malignancy-associated DM were more frequently male and over age 45 and less likely to have interstitial lung disease.
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影响因子：
10.3
作者：
Chen, YJ;Wu, CY;Shen, JL
通讯作者：
Shen, JL
影响因子：
39.2
作者：
Buchbinder, R;Forbes, A;Giles, G
通讯作者：
Giles, G
影响因子：
158.5
作者：
BOHAN, A;PETER, JB
通讯作者：
PETER, JB
影响因子：
--
作者：
BASSETSEGUIN, N;ROUJEAU, JC;TOURAINE, R
通讯作者：
TOURAINE, R
DOI：
10.1159/000248032
发表时间：
1990-01-01
期刊：
DERMATOLOGICA
影响因子：
--
作者：
BONNETBLANC, JM;BERNARD, P;FAYOL, J
通讯作者：
FAYOL, J