Quantification of the effect of treatment duration on local-regional failure after definitive concurrent chemotherapy and intensity-modulated radiation therapy for squamous cell carcinoma of the head and neck.
Quantification of the effect of treatment duration on local-regional failure after definitive concurrent chemotherapy and intensity-modulated radiation therapy for squamous cell carcinoma of the head and neck.
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DOI：
10.1002/hed.23024
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发表时间：
2013-05
影响因子：
2.9
通讯作者：
Singh, Anurag K.
中科院分区：
文献类型：
--
作者：
Platek, Mary E.;McCloskey, Susan A.;Cruz, Myra;Burke, Mark S.;Reid, Mary E.;Wilding, Gregory E.;Rigual, Nestor R.;Popat, Saurin R.;Loree, Thom R.;Gupta, Vishal;Warren, Graham W.;Sullivan, Maureen;Hicks, Wesley L., Jr.;Singh, Anurag K.
关键词：
这项研究的目的是量化治疗持续时间对头颈鳞状细胞癌(SCCHN)明确同期放化疗(CCRT)后局部区域进展的影响。我们对2004至2010年间接受治疗的患者进行了回顾性图表回顾。经过先前的分析，采取措施将治疗限制在7周以上。对第1组(2004-2007年，n=78)和第2组(2007-2010年，n=62)的结果进行了比较。队列之间的中位治疗时间差异有统计学意义：51天，队列1和46天，队列2(P<；.01)。在队列1和队列2中，局部区域进展分别为19%和5%(p=0.01)。在多变量分析中，与按时完成治疗的患者相比，延长治疗(≥57天)的患者局部区域进展的风险增加8倍(p<；.01)。在接受明确CCRT的SCCHN患者中，治疗时间是局部区域进展的重要预测因子。
The purpose of this study was to quantify the effect of treatment duration on locoregional progression after definitive concurrent chemoradiation (CCRT) for squamous cell carcinoma of the head and neck (SCCHN). We conducted a retrospective chart review of patients treated between 2004 and 2010. After a prior analysis, measures were taken to limit therapy beyond 7 weeks. Comparison of outcomes were made between cohorts 1 (2004–2007, n = 78) and 2 (2007–2010, n = 62). Median therapy duration was statistically significantly different between cohorts as follows: 51 days, cohort 1 and 46 days, cohort 2 (p < .01). Locoregional progression in cohorts 1 and 2 was 19% and 5% (p = .01), respectively. On multivariate analysis, patients with prolonged treatment (≥57 days) had an 8-fold increase in risk of locoregional progression compared to patients who completed on time (p < .01). Treatment duration was a significant predictor of locoregional progression in patients with SCCHN who received definitive CCRT.
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影响因子：
158.5
作者：
Brizel, DM;Albers, ME;Prosnitz, LR
通讯作者：
Prosnitz, LR
影响因子：
5.7
作者：
SLEVIN, NJ;HENDRY, JH;AGRENCRONQVIST, A
通讯作者：
AGRENCRONQVIST, A
影响因子：
45.3
作者：
Kies, MS;Haraf, DJ;Vokes, EE
通讯作者：
Vokes, EE
影响因子：
5.7
作者：
DUBBEN, HH
通讯作者：
DUBBEN, HH
DOI：
10.1002/hed.21640
发表时间：
2011-11-01
影响因子：
2.9
作者：
Platek, Mary E.;Reid, Mary E.;Singh, Anurag K.
通讯作者：
Singh, Anurag K.