Effects of maternal folic acid supplementation during the second and third trimesters of pregnancy on neurocognitive development in the child: an 11-year follow-up from a randomised controlled trial.
Effects of maternal folic acid supplementation during the second and third trimesters of pregnancy on neurocognitive development in the child: an 11-year follow-up from a randomised controlled trial.
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DOI：
10.1186/s12916-021-01914-9
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发表时间：
2021-03-10
期刊：
影响因子：
9.3
通讯作者：
Pentieva K
中科院分区：
文献类型：
--
作者：
Caffrey A;McNulty H;Rollins M;Prasad G;Gaur P;Talcott JB;Witton C;Cassidy T;Marshall B;Dornan J;Moore AJ;Ward M;Strain JJ;Molloy AM;McLaughlin M;Lees-Murdock DJ;Walsh CP;Pentieva K
孕妇在怀孕前和怀孕早期补充叶酸(FA)可以预防神经管缺陷(NTD)，但在怀孕早期继续补充FA是否对后代健康有好处尚不确定。我们的目的是评估怀孕期间补充FA对儿童认知能力和脑功能的影响。对居住在北爱尔兰的11岁儿童进行了跟踪调查，这些儿童的母亲参加了怀孕中期和晚期补充叶酸的随机试验，并从怀孕第14周开始每天服用400 μg FA或安慰剂。采用韦氏儿童智力量表评估认知能力(全量表智商、言语理解、工作记忆、知觉推理和加工速度)。用脑磁图(MEG)脑成像评估神经功能。在FASSTT试验的119对母子中，68名儿童在11年(2017年12月至2018年11月)的随访中接受了神经认知表现的评估。在符号搜索(平均差2.9分，95%可信区间0.3~5.5，p = 0.0 3)和取消(11.3分，2.5~2 0.1，p = 0.0 4)两个加工速度测试中，随机选择FA的母亲与安慰剂组的孩子的成绩显著高于安慰剂组，而对语言理解的积极影响仅在女孩中显著(6.5分，1.2至11.8，p= 0.0 3)。脑磁图对语言任务神经元反应的评估显示，补充FA的母亲的孩子在Beta(13-30 HZ，p = 0.01)和High Gamma(49-70 HZ，p = 0.04)频段的功率增加，这表明语言的语义加工更有效。在目前推荐的预防NTD的早期妊娠期后继续补充FA有助于儿童的神经认知发育。脑磁图在儿科研究中提供了一种非侵入性的工具，可以客观地评估营养和其他干预措施对大脑功能活动的影响。ISRCTN ISRCTN19917787。注册日期为2013年5月15日。网上版载有补充材料，可在10.1186/s12916-021-01914-9查阅。
Maternal folic acid (FA) supplementation before and in early pregnancy prevents neural tube defects (NTD), but it is uncertain whether continuing FA after the first trimester has benefits on offspring health. We aimed to evaluate the effect of FA supplementation throughout pregnancy on cognitive performance and brain function in the child. Follow-up investigation of 11-year-old children, residing in Northern Ireland, whose mothers had participated in a randomised trial of Folic Acid Supplementation in the Second and Third Trimesters (FASSTT) in pregnancy and received 400 μg/day FA or placebo from the 14th gestational week. Cognitive performance (Full Scale Intelligence Quotient, Verbal Comprehension, Working Memory, Perceptual Reasoning, and Processing Speed) was assessed using the Wechsler Intelligence Scale for Children. Neuronal function was assessed using magnetoencephalographic (MEG) brain imaging. Of 119 mother-child pairs in the FASSTT trial, 68 children were assessed for neurocognitive performance at 11-year follow-up (Dec 2017 to Nov 2018). Children of mothers randomised to FA compared with placebo scored significantly higher in two Processing Speed tests, i.e. symbol search (mean difference 2.9 points, 95% CI 0.3 to 5.5, p = 0.03) and cancellation (11.3 points, 2.5 to 20.1, p = 0.04), whereas the positive effect on Verbal Comprehension was significant in girls only (6.5 points, 1.2 to 11.8, p = 0.03). MEG assessment of neuronal responses to a language task showed increased power at the Beta (13–30 Hz, p = 0.01) and High Gamma (49–70 Hz, p = 0.04) bands in children from FA-supplemented mothers, suggesting more efficient semantic processing of language. Continued FA supplementation in pregnancy beyond the early period currently recommended to prevent NTD can benefit neurocognitive development of the child. MEG provides a non-invasive tool in paediatric research to objectively assess functional brain activity in response to nutrition and other interventions. ISRCTN ISRCTN19917787. Registered on 15 May 2013. The online version contains supplementary material available at 10.1186/s12916-021-01914-9.
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影响因子：
158.5
作者：
CZEIZEL, AE;DUDAS, I
通讯作者：
DUDAS, I
DOI：
10.1038/nrn.2018.1
发表时间：
2018-02-16
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Gilmore JH;Knickmeyer RC;Gao W
通讯作者：
Gao W
影响因子：
7.1
作者：
McNulty, Breige;McNulty, Helene;Pentieva, Kristina
通讯作者：
Pentieva, Kristina
影响因子：
4.2
作者：
Pfeiffer, Christine M.;Hughes, Jeffery P.;Johnson, Clifford L.
通讯作者：
Johnson, Clifford L.
影响因子：
7.1
作者：
Caffrey, Aoife;Irwin, Rachelle E.;Pentieva, Kristina
通讯作者：
Pentieva, Kristina