A Genetically Defined Compartmentalized Striatal Direct Pathway for Negative Reinforcement.
A Genetically Defined Compartmentalized Striatal Direct Pathway for Negative Reinforcement.
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DOI：
10.1016/j.cell.2020.08.032
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发表时间：
2020-10-01
期刊：
影响因子：
64.5
通讯作者：
Li B
中科院分区：
文献类型：
--
作者：
Xiao X;Deng H;Furlan A;Yang T;Zhang X;Hwang GR;Tucciarone J;Wu P;He M;Palaniswamy R;Ramakrishnan C;Ritola K;Hantman A;Deisseroth K;Osten P;Huang ZJ;Li B
背侧纹状体内的纹状体区室与强化学习和动机调节有关，但纹状体神经元如何对这些功能做出贡献仍然难以捉摸。在这里，我们表明，基因鉴定的纹状体人口，表达Teashirt家族锌指1（Tshz1），属于直接途径，驱动负强化，是必不可少的厌恶学习小鼠。与“传统”的纹状体直接通路相比，Tshz1神经元一旦被激活就会引起厌恶、运动抑制和负强化，并且它们接收一组不同的突触输入。这些神经元主要由惩罚而不是奖励兴奋，代表惩罚的预期或避免的动机。此外，抑制这些神经元会损害基于惩罚的学习，而不会影响奖励学习或运动。这些结果确立了纹状体神经元在惩罚强化行为中的重要作用，并揭示了经典模型中未解释的直接途径的功能。Xiao等人定义了对厌恶学习至关重要的动机行为直接通路的非常规成分，该成分在背侧纹状体的纹状体中富集，并代表惩罚以驱动小鼠的负强化。
The striosome compartment within the dorsal striatum has been implicated in reinforcement learning and regulation of motivation, but how striosomal neurons contribute to these functions remains elusive. Here, we show that a genetically identified striosomal population, which expresses the Teashirt family zinc finger 1 (Tshz1) and belongs to the direct pathway, drives negative reinforcement and is essential for aversive learning in mice. Contrasting a “conventional” striosomal direct pathway, the Tshz1 neurons cause aversion, movement suppression, and negative reinforcement once activated, and they receive a distinct set of synaptic inputs. These neurons are predominantly excited by punishment rather than reward and represent the anticipation of punishment or the motivation for avoidance. Furthermore, inhibiting these neurons impairs punishment-based learning without affecting reward learning or movement. These results establish a major role of striosomal neurons in behaviors reinforced by punishment and moreover uncover functions of the direct pathway unaccounted for in classic models. Xiao et al. define an unconventional component of the direct pathway for motivated behaviors crucial for aversive learning that is enriched in the striosome of the dorsal striatum and represents punishment to drive negative reinforcement in mice.
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DOI：
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发表时间：
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影响因子：
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作者：
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