Effectiveness of monovalent rotavirus vaccine in Bolivia: case-control study.
Effectiveness of monovalent rotavirus vaccine in Bolivia: case-control study.
复制标题
DOI：
10.1136/bmj.f3726
复制
发表时间：
2013-06-19
期刊：
影响因子：
--
通讯作者：
De Oliveira LH
中科院分区：
文献类型：
--
作者：
Patel MM;Patzi M;Pastor D;Nina A;Roca Y;Alvarez L;Iniguez V;Rivera R;Tam KI;Quaye O;Bowen M;Parashar U;De Oliveira LH
目的评价玻利维亚两剂轮状病毒单价疫苗（RV 1）预防轮状病毒感染的效果。设计病例对照研究。研究对象：2010年3月至2011年6月，玻利维亚的6家医院。参与者包括400名因轮状病毒而住院的患者，1200名非腹泻的医院对照组和718名轮状病毒阴性的医院对照组。主要结果测量病例患者和对照组之间既往接种疫苗的优势;接种疫苗的有效性（（1-校正优势比）×100），校正年龄和其他混杂因素;以及按剂量、疾病严重程度、年龄组和血清型分层的有效性。结果与非腹泻对照组相比，病例患者更可能是男性和参加日托，但不太可能有慢性基础疾病，母亲教育水平较高，家中有电话和电脑。轮状病毒阴性对照组与病例患者更相似，但也更可能是男性，参加日托，不太可能有较高水平的母亲教育和家中的计算机。RV 1对轮状病毒阴性对照组和非腹泻对照组的轮状病毒住院的校正有效性分别为69%（95%置信区间54%至79%）和77%（65%至84%）。一剂RV 1的有效率分别为36%和56%。在两个对照组中，保护作用持续两年，1岁以下儿童（64%和77%）和1岁以上儿童（72%和76%）住院的疗效相似。RV 1提供了针对不同血清型的显著保护，部分和完全异型于G1 P [8]疫苗。使用两个对照组对G9 P [8]的有效性分别为80%和85%，对G3 P [8]的有效性分别为74%和93%，对G2 P [4]的有效性分别为59%和69%，对G9 P [6]菌株的有效性分别为80%和87%。结论轮状病毒单价疫苗对玻利维亚儿童因轮状病毒腹泻住院具有高度保护作用。保护持续两年的生活对不同的血清型疫苗株。
Objective To evaluate the effectiveness of two doses of a monovalent rotavirus vaccine (RV1) against hospital admission for rotavirus in Bolivia. Design Case-control study. Setting Six hospitals in Bolivia, between March 2010 and June 2011. Participants 400 hospital admissions for rotavirus, 1200 non-diarrhea hospital controls, and 718 rotavirus negative hospital controls. Main outcome measures Odds of antecedent vaccination between case patients and controls; effectiveness of vaccination ((1–adjusted odds ratio)×100), adjusted for age and other confounders; and stratified effectiveness by dose, disease severity, age group, and serotype. Results In comparison with non-diarrhea controls, case patients were more likely to be male and attend day care but less likely to have chronic underlying illness, higher level maternal education, and telephones and computers in their home. Rotavirus negative controls were somewhat more similar to case patients but also were more likely to be male and attend day care and less likely to have higher level maternal education and computers in their homes. The adjusted effectiveness of RV1 against hospital admission for rotavirus was 69% (95% confidence interval 54% to 79%) with rotavirus negative controls and 77% (65% to 84%) with non-diarrhea controls. The effectiveness of one dose of RV1 was 36% and 56%, respectively. With both control groups, protection was sustained through two years of life, with similar efficacy against hospital admission among children under 1 year (64% and 77%) and over 1 year of age (72% and 76%). RV1 provided significant protection against diverse serotypes, partially and fully heterotypic to the G1P[8] vaccine. Effectiveness using the two control groups was 80% and 85% against G9P[8], 74% and 93%% against G3P[8], 59% and 69% against G2P[4], and 80% and 87% against G9P[6] strains. Conclusion The monovalent rotavirus vaccine conferred high protection against hospital admission for diarrhea due to rotavirus in Bolivian children. Protection was sustained through two years of life against diverse serotypes different from the vaccine strain.
登录
查看更多内容
影响因子：
6.4
作者：
Bahl, R;Ray, P;Bhan, MK
通讯作者：
Bhan, MK
影响因子：
8
作者：
Boom, Julie A.;Tate, Jacqueline E.;Parashar, Umesh D.
通讯作者：
Parashar, Umesh D.
影响因子：
5.5
作者：
Rivera, Luis;Pena, Lourdes Mendez;Han, Htay Htay
通讯作者：
Han, Htay Htay
影响因子：
7.2
作者：
SATTEN, GA;KUPPER, LL
通讯作者：
KUPPER, LL
影响因子：
8
作者：
Staat, Mary Allen;Payne, Daniel C.;Parashar, Umesh D.
通讯作者：
Parashar, Umesh D.