Genome-wide expression and methylation profiling in the aged rodent brain due to early-life Pb exposure and its relevance to aging.
Genome-wide expression and methylation profiling in the aged rodent brain due to early-life Pb exposure and its relevance to aging.
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DOI：
10.1016/j.mad.2012.05.003
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发表时间：
2012-06
影响因子：
5.3
通讯作者：
Zawia, Nasser H.
中科院分区：
文献类型：
--
作者：
Dosunmu, Remi;Alashwal, Hany;Zawia, Nasser H.
在这项研究中，我们评估了全球基因表达模式的青少年小鼠暴露于铅（铅）作为婴儿和他们的老年同胞，以确定重编程基因。分析出生后第20天和第700天的总体表达，鉴定下调和上调（≥2倍）的基因，聚类并分析其与DNA甲基化的关系。大约150个基因在老年时差异表达。在正常衰老过程中，我们观察到与免疫反应、金属结合、代谢和转录/转导偶联相关的基因上调。先前暴露于铅揭示了这些基因的抑制，这表明大脑发育阶段的干扰损害了抵御年龄相关应激源的能力，从而促进了神经退行性过程。基因的过表达和阻遏与其DNA甲基化谱相对应。
In this study, we assessed global gene expression patterns in adolescent mice exposed to lead (Pb) as infants and their aged siblings to identify reprogrammed genes. Global expression on postnatal day 20 and 700 was analyzed and genes that were down- and up-regulated (≥2 fold) were identified, clustered and analyzed for their relationship to DNA methylation. About 150 genes were differentially expressed in old age. In normal aging, we observed an up-regulation of genes related to the immune response, metal-binding, metabolism and transcription/transduction coupling. Prior exposure to Pb revealed a repression in these genes suggesting that disturbances in developmental stages of the brain compromise the ability to defend against age-related stressors, thus promoting the neurodegenerative process. Overexpression and repression of genes corresponded with their DNA methylation profile.
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影响因子：
7.4
作者：
Zawia, Nasser H.;Lahiri, Debomoy K.;Cardozo-Pelaez, Fernando
通讯作者：
Cardozo-Pelaez, Fernando
DOI：
10.3233/jad-2009-1138
发表时间：
2009
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Dosunmu R;Wu J;Adwan L;Maloney B;Basha MR;McPherson CA;Harry GJ;Rice DC;Zawia NH;Lahiri DK
通讯作者：
Lahiri DK
影响因子：
10.4
作者：
Weisskopf MG;Hu H;Sparrow D;Lenkinski RE;Wright RO
通讯作者：
Wright RO
影响因子：
10.4
作者：
Weuve J;Korrick SA;Weisskopf MG;Ryan LM;Schwartz J;Nie H;Grodstein F;Hu H
通讯作者：
Hu H
DOI：
10.1016/s0736-5748(02)00137-5
发表时间：
2003-02-01
影响因子：
1.8
作者：
Basha, MR;Wei, W;Zawia, NH
通讯作者：
Zawia, NH