Specific modulation of the root immune system by a community of commensal bacteria
Specific modulation of the root immune system by a community of commensal bacteria
复制标题
共生细菌群落对根部免疫系统的特异性调节
DOI：
10.1073/pnas.2100678118
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Finkel, Omri M.
中科院分区：
文献类型：
--
作者：
Teixeira, Paulo J. P. L.;Colaianni, Nicholas R.;Law, Theresa F.;Conway, Jonathan M.;Gilbert, Sarah;Li, Haofan;Salas-González, Isai;Panda, Darshana;Del Risco, Nicole M.;Finkel, Omri M.
植物有一个先天免疫系统，以抵御潜在的入侵者，这是基于非自我或修改自我分子的感知。微生物相关分子模式（MAMPs）是进化上保守的微生物分子，其通过特异性细胞表面受体的细胞外检测启动一系列生物化学反应，统称为MAMP-triggered immunity（MTI）。充分表征的MAMP包括几丁质、肽聚糖和flg 22，flg 22是在细菌鞭毛FliC的主要结构单元中发现的22个氨基酸的表位。通过植物免疫系统进行MAMP检测的重要性通过病原体用于干扰MTI的策略的巨大多样性来强调，并且不这样做通常与毒力的丧失相关。然而，MTI是否或如何超越致病相互作用的功能还没有很好地理解。在这里，我们证明了一个社区的根际细菌调制一个特定的和进化上保守的部门的thepisimmune系统。我们确定了一组强大的，分类学上不同的MTI抑制菌株，是有效的根殖民者，值得注意的是，可以提高其他测试的细菌的殖民能力。我们强调了MTI抑制的细胞外策略的重要性，通过显示2型，而不是3型，分泌系统是一个强大的MTI抑制剂的免疫调节活性所需的。我们的研究结果表明，根定殖的植物是由MTI，这反过来，可以选择性地调制的代表性细菌根微生物群的特定成员控制。
Plants have an innate immune system to fight off potential invaders that is based on the perception of nonself or modified-self molecules. Microbe-associated molecular patterns (MAMPs) are evolutionarily conserved microbial molecules whose extracellular detection by specific cell surface receptors initiates an array of biochemical responses collectively known as MAMP-triggered immunity (MTI). Well-characterized MAMPs include chitin, peptidoglycan, and flg22, a 22-amino acid epitope found in the major building block of the bacterial flagellum, FliC. The importance of MAMP detection by the plant immune system is underscored by the large diversity of strategies used by pathogens to interfere with MTI and that failure to do so is often associated with loss of virulence. Yet, whether or how MTI functions beyond pathogenic interactions is not well understood. Here we demonstrate that a community of root commensal bacteria modulates a specific and evolutionarily conserved sector of theArabidopsisimmune system. We identify a set of robust, taxonomically diverse MTI suppressor strains that are efficient root colonizers and, notably, can enhance the colonization capacity of other tested commensal bacteria. We highlight the importance of extracellular strategies for MTI suppression by showing that the type 2, not the type 3, secretion system is required for the immunomodulatory activity of one robust MTI suppressor. Our findings reveal that root colonization by commensals is controlled by MTI, which, in turn, can be selectively modulated by specific members of a representative bacterial root microbiota.
影响因子：
3.5
作者：
Kniskern, Joel M.;Traw, M. Brian;Bergelson, Joy
通讯作者：
Bergelson, Joy
影响因子：
9.2
作者：
Emonet, Aurelia;Zhou, Feng;Geldner, Niko
通讯作者：
Geldner, Niko
DOI：
10.1093/plcell/koab073
发表时间：
2021-07-19
期刊：
The Plant cell
影响因子：
--
作者：
Winkelmüller TM;Entila F;Anver S;Piasecka A;Song B;Dahms E;Sakakibara H;Gan X;Kułak K;Sawikowska A;Krajewski P;Tsiantis M;Garrido-Oter R;Fukushima K;Schulze-Lefert P;Laurent S;Bednarek P;Tsuda K
通讯作者：
Tsuda K