hUbiquitome: a database of experimentally verified ubiquitination cascades in humans.
hUbiquitome: a database of experimentally verified ubiquitination cascades in humans.
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hUbiquitome：经过实验验证的人类泛素化级联数据库
DOI：
10.1093/database/bar055
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Li T
中科院分区：
文献类型：
--
作者：
Du Y;Xu N;Lu M;Li T
蛋白质泛素化是通过E1激活酶、E2结合酶和E3连接酶的顺序作用实现的进化上保守且功能多样的翻译后修饰。总结了已验证的泛素化底物，并预测了酵母中的新底物。然而，一个系统的总结人类泛素化底物包含实验证据和酶级联的每种底物是不可用的。在本研究中，介绍了hUbiquitome网络资源，实验验证的人类泛素化酶和底物的检索的公共资源。hUbiquitome是第一个全面的人类泛素化级联数据库。目前，hUbiquitome在其库中有包括1种E1酶、12种E2酶、138种E3连接酶或复合物、279种不同的底物蛋白和17种去泛素化酶术语的数据。利用收集的数据分析了不同种类E3底物的生物学功能。研究结果表明，底物泛素化的RING（真正有趣的新基因）E3是丰富的最多的糖尿病相关的过程，而底物泛素化的其他E3是丰富的基因表达相关的过程。对数据的分析表明了不同种类的E3的生物过程偏好。hUbiquitome是第一个系统收集实验验证的泛素化蛋白和相关泛素化级联酶的数据库，这可能有助于泛素化修饰研究领域。数据库URL：http://202.38.126.151/hmdd/hubi/
Protein ubiquitination is an evolutionarily conserved and functionally diverse post-translational modification achieved through the sequential action of E1-activating enzymes, E2-conjugating enzymes and E3 ligases. A summary of validated ubiquitination substrates have been presented and a prediction of new substrates have been conducted in yeast. However, a systematic summary of human ubiquitination substrates containing experimental evidence and the enzymatic cascade of each substrate is not available. In the present study, hUbiquitome web resource is introduced, a public resource for the retrieval of experimentally verified human ubiquitination enzymes and substrates. hUbiquitome is the first comprehensive database of human ubiquitination cascades. Currently, hUbiquitome has in its repertoire curated data comprising 1 E1 enzyme, 12 E2 enzymes, 138 E3 ligases or complexes, 279 different substrate proteins and 17 deubiquitination enzyme terms. The biological functions of substrates from different kinds of E3s were analyzed using the collected data. The findings show that substrates ubiquitinated by RING (Really Interesting New Gene) E3s are enriched most in apoptosis-related processes, whereas substrates ubiquitinated by other E3s are enriched in gene expression-associated processes. An analysis of the data demonstrates the biological process preferences of the different kinds of E3s. hUbiquitome is the first database to systematically collect experimentally validated ubiquitinated proteins and related ubiquitination cascade enzymes which might be helpful in the field of ubiquitination-modification research. Database URL: http://202.38.126.151/hmdd/hubi/
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影响因子：
3.9
作者：
Katz, Elijah J.;Isasa, Marta;Crosas, Bernat
通讯作者：
Crosas, Bernat
影响因子：
14.8
作者：
Huang, Da Wei;Sherman, Brad T.;Lempicki, Richard A.
通讯作者：
Lempicki, Richard A.
影响因子：
4.4
作者：
Lee WC;Lee M;Jung JW;Kim KP;Kim D
通讯作者：
Kim D
影响因子：
4.4
作者：
Meierhofer, David;Wang, Xiaorong;Huang, Lan;Kaiser, Peter
通讯作者：
Kaiser, Peter
DOI：
10.1098/rstb.1999.0495
发表时间：
1999-09-29
期刊：
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
影响因子：
--
作者：
Hochstrasser, M;Johnson, PR;Connerly, PL
通讯作者：
Connerly, PL