Yeast sirtuins and the regulation of aging.
Yeast sirtuins and the regulation of aging.
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DOI：
10.1111/1567-1364.12115
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发表时间：
2014-02
影响因子：
3.2
通讯作者：
Smith JS
中科院分区：
文献类型：
--
作者：
Wierman MB;Smith JS
Sirtuins是NAD+依赖性蛋白质脱乙酰酶的遗传学保守家族，其对于每个脱乙酰化的赖氨酸侧链消耗一个NAD+分子。它们对NAD+的需求可能使它们易于受到NAD+或生物合成中间体波动的调节，从而将它们与细胞代谢联系起来。来自酿酒酵母的Sir2蛋白是沉默调节蛋白家族的创始成员，并且已被充分表征为组蛋白脱乙酰基酶，其在异染色质结构域的转录沉默中起作用，并且作为复制寿命的促长寿因子，复制寿命定义为母细胞在衰老之前分裂（芽）的次数。删除SIR2会缩短复制寿命，而增加基因剂量会导致延长。此外，Sir2不仅在酵母中，而且在高等真核生物中都参与介导热量限制对寿命的有益影响。虽然这种模式有其分歧和辩论的份额，它也有助于迅速推动老龄化研究领域向前发展。S.酿酒酵母具有四种额外的sirtuins，Hst 1，Hst 2，Hst 3和Hst 4。这篇综述讨论了Sir2和Hst同源物在复制性衰老和时序性衰老中的功能，并讨论了sirtuins如何在响应环境应激（如热量限制）时进行调节。
The Sirtuins are a phylogenetically conserved family of NAD+ dependent protein deacetylases that consume one molecule of NAD+ for every deacetylated lysine side chain. Their requirement for NAD+ potentially makes them prone to regulation by fluctuations in NAD+ or biosynthesis intermediates, thus linking them to cellular metabolism. The Sir2 protein from Saccharomyces cerevisiae is the founding sirtuin family member and has been well characterized as a histone deacetylase that functions in transcriptional silencing of heterochromatin domains and as a pro longevity factor for replicative lifespan, defined as the number of times a mother cells divides (buds) before senescing. Deleting SIR2 shortens replicative lifespan, while increased gene dosage causes extension. Furthermore, Sir2 has been implicated in mediating the beneficial effects of caloric restriction on lifespan, not only in yeast, but also higher eukaryotes. While this paradigm has had its share of disagreements and debate, it has also helped rapidly drive the aging research field forward. S. cerevisiae has four additional sirtuins, Hst1, Hst2, Hst3, and Hst4. This review discusses the function of Sir2 and the Hst homologs in replicative aging and chronological aging, and also addresses how the sirtuins are regulated in response to environmental stresses such as caloric restriction.
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影响因子：
7.8
作者：
Delaney JR;Sutphin GL;Dulken B;Sim S;Kim JR;Robison B;Schleit J;Murakami CJ;Carr D;An EH;Choi E;Chou A;Fletcher M;Jelic M;Liu B;Lockshon D;Moller RM;Pak DN;Peng Q;Peng ZJ;Pham KM;Sage M;Solanky A;Steffen KK;Tsuchiya M;Tsuchiyama S;Johnson S;Raabe C;Suh Y;Zhou Z;Liu X;Kennedy BK;Kaeberlein M
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通讯作者：
BOEKE, JD
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作者：
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通讯作者：
Taddei, Angela
影响因子：
16
作者：
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通讯作者：
Guarente, L
影响因子：
4.3
作者：
Burtner, Christopher R.;Murakami, Christopher J.;Kaeberlein, Matt
通讯作者：
Kaeberlein, Matt