Characterizing the phenotypic and genetic structure of psychopathology in UK Biobank.
Characterizing the phenotypic and genetic structure of psychopathology in UK Biobank.
复制标题
描述英国生物银行中精神病理学的表型和遗传结构。
DOI：
10.1101/2023.09.05.23295086
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Ramus,Franck
中科院分区：
文献类型：
--
作者：
Williams,CamilleM;Peyre,Hugo;Wolfram,Tobias;Lee,YoungaH;Ge,Tian;Smoller,JordanW;Mallard,TravisT;Ramus,Franck
Mental health conditions are characterized by higher-order transdiagnostic factor structures, which may contribute to the high levels of comorbidity observed in psychopathology. However, the phenotypic and genetic structures of various psychopathology diagnoses may differ, raising questions about the validity and utility of these factors. Here we study the phenotypic and genetic factor structures of ten psychiatric conditions using UK Biobank and public genomic data. Although the factor structure of psychopathology was generally genetically and phenotypically consistent, conditions related to externalizing (for example, alcohol use disorder) and compulsivity (for example, eating disorders) exhibited cross-level disparities in their relationships with other conditions, possibly due to environmental influences. Domain-level factors, especially thought disorder and internalizing factors, were more informative than a general psychopathology factor in genome-wide association and polygenic index analyses. Collectively, our findings enhance the understanding of comorbidity and shared etiology, highlight the intricate interplay between genes and environment, and offer guidance for psychiatric research using polygenic indices.
登录
查看更多内容
小鼠T细胞抗原受体α家族基因的多样性和结构
影响因子：
64.8
作者：
B. Arden;J. Klotz;G. Siu;L. Hood
通讯作者：
L. Hood
DOI：
10.1073/pnas.83.11.3934
发表时间：
1986-06
影响因子：
11.1
作者：
K. Huebner;A. Ar-rushdi;C. Griffin;M. Isobe;C. Kozak;B. Emanuel;L. Nagarajan;J. Cleveland;T. Bonner;M. Goldsborough
通讯作者：
K. Huebner;A. Ar-rushdi;C. Griffin;M. Isobe;C. Kozak;B. Emanuel;L. Nagarajan;J. Cleveland;T. Bonner;M. Goldsborough
新的染色体易位与儿童急性淋巴细胞白血病的特异性免疫表型相关
影响因子：
64.5
作者：
DorothyL. Williams;A. Look;S. Melvin;P. Roberson;G. Dahl;Terri Flake;S. Stass
通讯作者：
S. Stass
T 细胞白血病和淋巴瘤 14 号染色体上的共同区域。
影响因子：
56.9
作者：
F. Hecht;R. Morgan;B. Hecht;S. Smith
通讯作者：
S. Smith
DOI：
10.1073/pnas.80.22.6922
发表时间：
1983-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
CROCE, CM;THIERFELDER, W;NOWELL, PC
通讯作者：
NOWELL, PC