ZHX2 inhibits thyroid cancer metastasis through transcriptional inhibition of S100A14.
ZHX2 inhibits thyroid cancer metastasis through transcriptional inhibition of S100A14.
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DOI：
10.1186/s12935-022-02499-w
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发表时间：
2022-02-12
影响因子：
5.8
通讯作者：
Yue X
中科院分区：
文献类型：
--
作者：
Zhang Y;Sun M;Gao L;Liang X;Ma C;Lu J;Yue X
甲状腺癌是最常见的恶性内分泌肿瘤，转移已成为治疗失败的主要原因。然而，甲状腺癌转移的潜在分子机制仍然知之甚少。我们研究了抑癌基因锌指和同源盒2(ZHX2)在甲状腺癌转移中的作用。为了研究ZHX2在甲状腺癌转移中的作用，我们通过细胞迁移、伤口愈合和肺转移肿瘤形成的体外和体内模型评价了EMT过程。ZHX2在甲状腺癌组织中的表达显著降低，与甲状腺癌患者的预后不良有关。ZHX2基因敲除显著促进了甲状腺癌细胞的迁移。机制上，ZHX2与S100钙结合蛋白A14(S100A14)启动子结合，降低S100A14的转录。此外，S100A14在人甲状腺癌组织中高表达，其表达与ZHX2表达呈负相关。抑制S100A14可减弱ZHX2基因敲除诱导的甲状腺癌细胞在体内外的转移增强。这些证据表明，ZHX2通过阻断S100A14介导的转移来抑制甲状腺癌的进展。网上版载有补充材料，可在10.1186/s12935-022-02499-w查阅。
Thyroid cancer is the most common malignant endocrine tumour, and metastasis has become the main reason for treatment failure. However, the underlying molecular mechanism of thyroid cancer metastasis remains poorly understood. We investigated the role of the tumour suppressor zinc fingers and homeoboxes 2 (ZHX2) in the metastasis of thyroid cancer. To study the role of ZHX2 in thyroid cancer metastasis, we evaluated the EMT process using cell migration, wound healing and lung metastatic tumour formation in vitro and in vivo models. ZHX2 expression was significantly decreased in thyroid cancer tissues, which correlated with poor prognosis of thyroid cancer patients. ZHX2 knockdown significantly promoted the migration of thyroid cancer cells. Mechanistically, ZHX2 associated with the S100 calcium binding protein A14 (S100A14) promoter to decrease the transcription of S100A14. Moreover, S100A14 was highly expressed in human thyroid cancer samples, and its expression negatively correlated with ZHX2 expression. Inhibition of S100A14 attenuated the ZHX2 knockdown-induced enhanced metastasis of thyroid cancer cells both in vitro and in vivo. The evidence presented here suggests that ZHX2 inhibits the progression of thyroid cancer by blocking S100A14-mediated metastasis. The online version contains supplementary material available at 10.1186/s12935-022-02499-w.
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影响因子：
--
作者：
Nagaiah G;Hossain A;Mooney CJ;Parmentier J;Remick SC
通讯作者：
Remick SC
影响因子：
3.9
作者：
Lv N;Liu F;Cheng L;Liu F;Kuang J
通讯作者：
Kuang J
影响因子：
78.5
作者：
Bresnick, Anne R.;Weber, David J.;Zimmer, Danna B.
通讯作者：
Zimmer, Danna B.
ZHX2通过干扰NF-YA抑制MDR1增强化疗药物对肝肿瘤细胞的细胞毒性
影响因子：
--
作者：
Ma H;Yue X;Gao L;Liang X;Yan W;Zhang Z;Shan H;Zhang H;Spear BT;Ma C
通讯作者：
Ma C
影响因子：
5.4
作者：
Ji, Yi-Fei;Huang, Hua;Xiao, Ming-Bing
通讯作者：
Xiao, Ming-Bing