Cancer Risk by Attained Age among Children with Birth Defects in Arkansas.
Cancer Risk by Attained Age among Children with Birth Defects in Arkansas.
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阿肯色州出生缺陷的儿童达到的癌症风险。
DOI：
10.1016/j.canep.2020.101796
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发表时间：
2020-10
影响因子：
2.6
通讯作者：
Nembhard WN
中科院分区：
文献类型：
--
作者：
Patel J;Schraw JM;Lupo PJ;Mian A;Nembhard WN
很少有研究评估出生缺陷与达到年龄的儿科癌症风险之间的关联。因此，我们评估了有和没有出生缺陷的儿童在达到年龄时患癌症的风险。我们通过链接来自阿肯色州生殖健康监测系统、阿肯色州中央癌症登记处和出生证明的数据，检查了1996年至2011年间出生的≤14岁有和无出生缺陷儿童的癌症风险。患癌症的年龄计算为从出生到癌症诊断、死亡或研究期结束（以先发生者为准）的人-年。使用考克斯比例风险模型，我们评估了达到年龄组（<1岁，1-4岁，5-9岁和10- 1 - 4岁）之间的关联：（1）出生缺陷组（任何，染色体和非染色体）和任何癌症;（2）器官系统和任何癌症的非染色体出生缺陷;（3）非染色体出生缺陷和癌症亚型。在629，086名儿童中，23，341名（3.7%）儿童患有出生缺陷，1，037名（0.2%）儿童患有癌症。对于患有非染色体出生缺陷的儿童，特别是心血管和泌尿生殖系统缺陷的儿童，在生命的第一年观察到任何癌症的最高风险（风险比[HR] 18.5; 95%置信区间[CI] 10.1-33.8）。对于染色体出生缺陷儿童，在1-4岁儿童中观察到癌症风险增加（HR 20.0; 95% CI 8.3-48.4）。总体而言，出生缺陷儿童的癌症风险在<5岁的儿童中最高。我们的研究结果与以前的研究一致，可能会为出生缺陷儿童的监测策略提供信息。
Few studies have evaluated associations between birth defects and risk of pediatric cancers by age of attainment. Therefore, we assessed the risk of cancer among children with and without birth defects by age at attainment. We examined cancer risk in children ≤14 years with and without birth defects born between 1996 and 2011 by linking data from the Arkansas Reproductive Health Monitoring System, Arkansas Central Cancer Registry, and birth certificates. Age of attainment for cancer was calculated as person-years from birth to cancer diagnosis, death, or end of study period, whichever occurred first. Using Cox proportional hazards models, we evaluated associations by attained age groups (<1, 1-4, 5-9, and 10-14 years) between: (1) groups of birth defects (any, chromosomal, and non-chromosomal) and any cancer; (2) non-chromosomal birth defects by organ system and any cancer; and (3) non-chromosomal birth defects and subtypes of cancer. In the cohort of 629,086 children, 23,341 (3.7%) children had birth defects and 1,037 (0.2%) children had cancer. For children with non-chromosomal birth defects, specifically cardiovascular and genitourinary, highest risk of any cancer was observed in first year of life (Hazard Ratio [HR] 18.5; 95% confidence interval [CI] 10.1-33.8). For children with chromosomal birth defects, increased cancer risk was observed among those 1-4 years-old (HR 20.0; 95% CI 8.3-48.4). Overall, cancer risk among children with birth defects was highest among those <5 years-old. Our findings, consistent with previous studies, may inform surveillance strategies for children with birth defects.
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影响因子：
8
作者：
Bjorge, Tone;Sorensen, Henrik Toft;Troisi, Rebecca
通讯作者：
Troisi, Rebecca
影响因子：
3.7
作者：
Norwood, Marlena S.;Lupo, Philip J.;Mueller, Beth A.
通讯作者：
Mueller, Beth A.
影响因子：
5
作者：
MILI, F;LYNCH, CF;EDMONDS, LD
通讯作者：
EDMONDS, LD
影响因子：
2.8
作者：
Lupo, Philip J.;Symanski, Elaine;Langlois, Peter H.
通讯作者：
Langlois, Peter H.
影响因子：
5.1
作者：
LITTLEFIELD, JW
通讯作者：
LITTLEFIELD, JW