The interaction mechanism between autophagy and apoptosis in colon cancer.
The interaction mechanism between autophagy and apoptosis in colon cancer.
复制标题
结肠癌自噬与凋亡的相互作用机制
DOI：
10.1016/j.tranon.2020.100871
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发表时间：
2020-12
影响因子：
5
通讯作者：
Li X
中科院分区：
文献类型：
--
作者：
Xie Q;Liu Y;Li X
自噬和凋亡在肿瘤发生中起着重要作用。近年来的研究表明，自噬和凋亡在抗肿瘤治疗中存在相互作用的关系。细胞凋亡是肿瘤细胞死亡的主要途径之一。而自噬在肿瘤中的作用则相反：保护性自噬和致死性自噬。保护性自噬可抑制抗癌药物诱导的肿瘤细胞凋亡，而致死性自噬可协同抗癌药物诱导肿瘤细胞凋亡。因此，自噬和凋亡在肿瘤中具有协同和拮抗作用。结直肠癌是一种常见的恶性肿瘤，发病率和死亡率都很高。近年来，结直肠癌的药物治疗取得了改善的临床疗效。尽管如此，耐药性的增加限制了治疗效果，突出了探索驱动耐药性的分子事件的紧迫性。研究人员发现，自噬是导致结肠癌耐药的主要因素之一。因此，阐明自噬与凋亡之间的相互作用有助于提高抗癌药物在大肠癌临床治疗中的疗效。本文就大肠癌中自噬与凋亡的关系及其相关因素作一综述。
Autophagy and apoptosis play crucial roles in tumorigenesis. Recent studies have shown that autophagy and apoptosis have a cross-talk relationship in anti-tumor therapy. It is well established that apoptosis is one of the main pathways of tumor cell death. While autophagy can occurs in tumors with opposite function: protective autophagy and lethal autophagy. Protective autophagy can inhibit tumor apoptosis induced by anticancer drugs, while lethal autophagy can induce tumor cell apoptosis in cooperation with anticancer drugs. Hence, autophagy and apoptosis have synergistic and antagonistic effects in tumor. Colorectal cancer is a common malignant tumor with high morbidity and mortality. In recent years, colorectal carcinoma has achieved improved clinical efficacy with drug treatment. Nonetheless, increasing drug-resistance limit the treatment efficacy, highlighting the urgency of exploring the molecular events that drive drug resistance. Researchers have found that autophagy is one of the major factors leading to drug resistance in colon cancer. Therefore, elucidating the interaction between autophagy and apoptosis is helpful to improve the efficacy of anticancer drugs in clinical treatment of colorectal cancer. This review attaches great importance to the relationship between autophagy and apoptosis and related factors in colorectal cancer.
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DOI：
10.1186/1478-811x-8-31
发表时间：
2010-12-22
期刊：
Cell communication and signaling : CCS
影响因子：
--
作者：
Chaitanya GV;Steven AJ;Babu PP
通讯作者：
Babu PP
DOI：
10.1016/j.biocel.2013.02.007
发表时间：
2013-05-01
影响因子：
4
作者：
Fu, Lei-lei;Cheng, Yan;Liu, Bo
通讯作者：
Liu, Bo
影响因子：
64.5
作者：
Green DR;Levine B
通讯作者：
Levine B
影响因子：
--
作者：
Fesler A;Liu H;Wu N;Liu F;Ling P;Ju J
通讯作者：
Ju J
影响因子：
4.2
作者：
Coker-Gurkan, Ajda;Arisan, Elif Damla;Palavan-Unsal, Narcin
通讯作者：
Palavan-Unsal, Narcin