Update on amyloid imaging: from healthy aging to Alzheimer's disease.
Update on amyloid imaging: from healthy aging to Alzheimer's disease.
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DOI：
10.1007/s11910-009-0051-4
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发表时间：
2009-09
影响因子：
5.6
通讯作者：
Klunk, William E.
中科院分区：
文献类型：
--
作者：
Wolk, David A.;Klunk, William E.
We report on the current state of in vivo amyloid imaging. While this technique is less than a decade old, a wealth of information is emerging as the initial clinical studies are reported. Imaging of patients with Alzheimer's Disease (AD) have allowed for quantitative exploration of the natural history of amyloid deposition and it's relationship to neurodegeneration. Amyloid imaging also shows significant promise in differential diagnosis of mild cognitive impairment or atypical dementias. However, amyloid detection may be of greatest utility in healthy elderly in whom amyloid imaging has confirmed prior autopsy reports of a significant percentage of asymptomatic adults with Alzheimer's pathology. Understanding the relationship between this pathology and future cognitive status has significant implications for the application of disease modifying medications in the ‘pre-clinical’ phase of disease. Given the considerable clinical experience compared to other tracers, the current review focuses on the literature involving Pittsburgh Compound-B (PiB) PET.
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通讯作者：
Klunk, William E.