Association Between Perforating Scleral Vessel and Myopic Maculopathy: A Cross-Sectional Study of a Chinese Cohort.
Association Between Perforating Scleral Vessel and Myopic Maculopathy: A Cross-Sectional Study of a Chinese Cohort.
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DOI：
10.3389/fmed.2021.727680
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发表时间：
2021
影响因子：
3.9
通讯作者：
Sun X
中科院分区：
文献类型：
--
作者：
Yu H;Sun J;Luo H;Wang Z;Sun X
目的：探讨高度近视人群中巩膜穿通血管（PSV）与不同类型近视性黄斑病变（MM）的关系。方法：共纳入188只高度近视眼（117例参与者）。每位参与者都接受了详细的病史和眼科检查。根据眼底照片和光学相干断层扫描，将患者分为非MM组和MM组。根据新的分类系统（ATN），MM病例被分类为近视萎缩性黄斑病变（MAM）、近视牵拉性黄斑病变（MTM）和近视新生血管性黄斑病变（MNM）。测量PSV数目和黄斑区脉络膜厚度（mChT）。结果如下：与非MM组相比，MM组的年龄相对较大（48.40 vs. 32.34; p < 0.001），更长的轴向长度（AL，29.72 vs. 27.75，p < 0.001），mChT较薄（52.90 vs. 122.52; p < 0.001），PSV计数较低（6.73 vs. 9.47，p ≤ 0.001）。与MM组相比，非MM组在总面积（0-9 mm，9.47 vs. 6.73，p < 0.001）和中央凹周围面积（3-9 mm，7.25 vs. 4.71，p < 0.001）中的PSV计数更高。单变量和多变量分析显示PSV计数与MAM（p = 0.2419）和MTM（p = 0.5678）无关。总PSV计数[比值比（OR）0.78，95%CI 0.64-0.95，p = 0.0149]和中央凹周围PSV计数（OR 0.80，95%CI 0.65-0.98，p = 0.0299）均为MNM的保护因素。分层分析显示，在AL <28 mm、mChT <50 μm、mChT ≥100 μm和有睫状视网膜动脉的眼中，PSV计数与MNM无显著相关性。结论：中心凹周围区（中心凹3-9 mm）和中心凹总面积（中心凹0-9 mm）的PSV计数较高是MNM的保护因素，而PSV计数与MAM和MTM无关。这些发现可能为病理性近视的发病机制提供新的见解。
Purpose: To investigate the association between perforating scleral vessel (PSV) and different types of myopic maculopathy (MM) in a highly myopic population. Methods: In total, 188 highly myopic eyes (117 participants) were enrolled. Each participant underwent detailed history taking and ocular examinations. Based on fundus photographs and optical coherence tomography, patients were subdivided into the non-MM group and MM group. Based on a new classification system (ATN), MM cases were classified as myopic atrophy maculopathy (MAM), myopic tractional maculopathy (MTM), and myopic neovascular maculopathy (MNM). The number of PSV and the macular choroidal thickness (mChT) were measured. Results: Compared with non-MM group, MM group was characterized by relatively larger age (48.40 vs. 32.34; p < 0.001), longer axial length (AL, 29.72 vs. 27.75, p < 0.001), thinner mChT (52.90 vs. 122.52; p < 0.001), and lower PSV counts (6.73 vs. 9.47, p ≤ 0.001). The non-MM group had higher PSV counts in total area (0–9 mm, 9.47 vs. 6.73, p < 0.001) and perifovea area (3–9 mm, 7.25 vs. 4.71, p < 0.001) compared to the MM group. Univariate and multivariate analyses showed that PSV count had no association with MAM (p = 0.2419) and MTM (p = 0.5678). Total PSV count [odds ratio (OR) 0.78, 95% CI 0.64–0.95, p = 0.0149] and perifovea PSV count (OR 0.80, 95% CI 0.65–0.98, p = 0.0299) were both protective factors for MNM. The stratified analysis revealed that in groups with AL <28 mm, or mChT <50 μm, or mChT ≥100 μm, or eyes with cilioretinal artery, PSV count had no significant association with MNM. Conclusion: Higher PSV counts in perifovea area (3–9 mm centered fovea) and total area (0–9 mm centered fovea) were protective factors for MNM, whereas PSV count had no association with MAM and MTM. These findings may provide novel insights into the mechanisms of pathologic myopia.
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影响因子：
4.4
作者：
Al-Sheikh, Mayss;Phasukkijwatana, Nopasak;Sarraf, David
通讯作者：
Sarraf, David
影响因子：
4.2
作者：
Querques, Giuseppe;Corvi, Federico;Bandello, Francesco
通讯作者：
Bandello, Francesco
影响因子：
4.4
作者：
Pedinielli, Alexandre;Souied, Eric H.;Querques, Giuseppe
通讯作者：
Querques, Giuseppe
DOI：
10.1097/iae.0000000000001686
发表时间：
2018-06-01
影响因子：
3.3
作者：
Rothenbuehler, Simon P.;Maloca, Peter;Hasler, Pascal W.
通讯作者：
Hasler, Pascal W.
高度近视眼的睫状体视网膜动脉：摄影分类系统及其与近视黄斑变性的关联
影响因子：
3.9
作者：
Meng J;Wei L;Zhang K;He W;Lu Y;Zhu X
通讯作者：
Zhu X