Three-dimensional characterization of resorption cavity size and location in human vertebral trabecular bone.
Three-dimensional characterization of resorption cavity size and location in human vertebral trabecular bone.
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DOI：
10.1016/j.bone.2012.03.028
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发表时间：
2012-07
期刊：
影响因子：
4.1
通讯作者：
Hernandez CJ
中科院分区：
文献类型：
--
作者：
Goff MG;Slyfield CR;Kummari SR;Tkachenko EV;Fischer SE;Yi YH;Jekir MG;Keaveny TM;Hernandez CJ
松质骨中吸收腔的数量和大小被认为影响骨丢失率、局部组织应力和应变以及潜在的全骨强度。传统的测量松质骨吸收空腔的二维方法报告了空腔或破骨细胞覆盖的骨表面百分比，但无法测量空腔数量或尺寸。在这里，我们使用三维成像（体素尺寸0.7 × 0.7 × 5.0 μm）来表征来自9名老年供体（7名男性，2名女性，年龄47-80岁）的人椎体松质骨中吸收腔的位置、数量和大小。空洞的最大深度为30.10 ± 8.56 μm，表面积为80.60 ± 22.23 *103 μm2，体积为614.16 ± 311.93 *103 μm3（平均值± SD）。每单位组织体积的平均空洞数（N.Cv/TV）为1.25 ± 0.77 mm−3。最大空洞深度与局部骨小梁厚度的比值为30.46 ± 7.03%，骨小梁越厚，最大空洞深度越大（p < 0.05，r2 = 0.14）。一半的吸收腔完全位于小梁结构内的节点（两个或多个小梁的交叉点）上。不完全位于结节上的腔主要位于颅尾（纵向）方向的板状小梁上。板状骨小梁上的空洞在最大空洞深度、空洞表面积和空洞体积方面均大于杆状骨小梁上的空洞（p < 0.05）。我们从这些发现中得出结论，空洞的大小和位置与局部小梁微结构有关。
The number and size of resorption cavities in cancellous bone are believed to influence rates of bone loss, local tissue stress and strain and potentially whole bone strength. Traditional two-dimensional approaches to measuring resorption cavities in cancellous bone report the percent of the bone surface covered by cavities or osteoclasts, but cannot measure cavity number or size. Here we use three-dimensional imaging (voxel size 0.7 × 0.7 × 5.0 μm) to characterize resorption cavity location, number and size in human vertebral cancellous bone from nine elderly donors (7 male, 2 female, ages 47–80 years). Cavities were 30.10 ± 8.56 μm in maximum depth, 80.60 ± 22.23 *103 μm2 in surface area and 614.16 ± 311.93 *103 μm3 in volume (mean ± SD). The average number of cavities per unit tissue volume (N.Cv/TV) was 1.25 ± 0.77 mm−3. The ratio of maximum cavity depth to local trabecular thickness was 30.46 ± 7.03 % and maximum cavity depth was greater on thicker trabeculae (p < 0.05, r2 = 0.14). Half of the resorption cavities were located entirely on nodes (the intersection of two or more trabeculae) within the trabecular structure. Cavities that were not entirely on nodes were predominately on plate-like trabeculae oriented in the cranial-caudal (longitudinal) direction. Cavities on plate-like trabeculae were larger in maximum cavity depth, cavity surface area and cavity volume than cavities on rod-like trabeculae (p < 0.05). We conclude from these findings that cavity size and location are related to local trabecular microarchitecture.
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影响因子：
10.6
作者：
Carr, JC;Fright, WR;Beatson, RK
通讯作者：
Beatson, RK
影响因子：
4.2
作者：
Gentzsch, C;Pueschel, K;Kaiser, E
通讯作者：
Kaiser, E
影响因子：
4.1
作者：
GARRAHAN, NJ;CROUCHER, PI;COMPSTON, JE
通讯作者：
COMPSTON, JE
影响因子：
6.2
作者：
ERIKSEN, EF;HODGSON, SF;RIGGS, BL
通讯作者：
RIGGS, BL
影响因子：
6.2
作者：
Liu, X. Sherry;Sajda, Paul;Guo, X. Edward
通讯作者：
Guo, X. Edward