Iron Absorption from Iron-Biofortified Sweetpotato Is Higher Than Regular Sweetpotato in Malawian Women while Iron Absorption from Regular and Iron-Biofortified Potatoes Is High in Peruvian Women.
Iron Absorption from Iron-Biofortified Sweetpotato Is Higher Than Regular Sweetpotato in Malawian Women while Iron Absorption from Regular and Iron-Biofortified Potatoes Is High in Peruvian Women.
复制标题
马拉维妇女从铁生物强化甘薯中吸收的铁高于常规甘薯，而秘鲁妇女从常规和铁生物强化马铃薯中吸收的铁较高。
DOI：
10.1093/jn/nxaa267
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发表时间：
2020-12-10
期刊：
影响因子：
--
通讯作者：
Wegmüller R
中科院分区：
文献类型：
--
作者：
Jongstra R;Mwangi MN;Burgos G;Zeder C;Low JW;Mzembe G;Liria R;Penny M;Andrade MI;Fairweather-Tait S;Zum Felde T;Campos H;Phiri KS;Zimmermann MB;Wegmüller R
甘薯和马铃薯是快速成熟的主要作物，在低收入和中等收入国家广泛消费。用铁对这些作物进行生物强化的传统育种可以提高铁的摄入量。据我们所知，尚未评估甘薯和马铃薯的铁吸收。目的是评估铁的吸收，从普通和铁生物强化橙色肉甘薯在马拉维和黄色肉马铃薯和铁生物强化紫色肉马铃薯在秘鲁。我们在一般健康、铁缺乏的育龄妇女中进行了2项随机、多餐研究。马拉维妇女（n = 24）接受400克常规或生物强化甘薯试验餐，秘鲁妇女（n = 35）接受500克常规或生物强化马铃薯试验餐。妇女在早餐时食用2周，然后交叉到其他品种。我们用57 Fe或58 Fe标记测试餐，并在每个测试餐序列完成后14天测量标记的累积红细胞掺入，以计算铁吸收。通过配对样本t检验比较铁吸收。常规和生物强化的橙肉甘薯测试餐含有0.55和0.97 mg Fe/100 g。铁吸收分数（FIA）的几何平均值（95% CI）分别为5. 82%（3. 79%，8. 95%）和6. 02%（4. 51%，8. 05%）（P = 0. 81），导致生物强化甘薯的总铁吸收（TIA）增加1. 9倍（P <0. 001）。常规和生物强化马铃薯测试餐含有0.33和0.69 mg Fe/100 g。普通黄肉马铃薯粉和生物强化紫肉马铃薯粉的FIA分别为28.4%（23.5%，34.2%）和13.3%（10.6%，16.6%）（P < 0.001），TIA差异不显著（P = 0.88）。来自普通黄肉马铃薯的FIA非常高，为28%。从两种马铃薯测试餐中吸收的铁占育龄妇女每日吸收铁需求量的33%，而生物强化的橙肉甘薯测试餐占这一需求量的18%。高浓度的多酚可能是铁吸收的主要抑制剂。这些试验在www.clinicaltrials.gov上登记为NCT 03840031（马拉维）和NCT 04216030（秘鲁）。
Sweetpotato and potato are fast-maturing staple crops and widely consumed in low- and middle-income countries. Conventional breeding to biofortify these crops with iron could improve iron intakes. To our knowledge, iron absorption from sweetpotato and potato has not been assessed. The aim was to assess iron absorption from regular and iron-biofortified orange-fleshed sweetpotato in Malawi and yellow-fleshed potato and iron-biofortified purple-fleshed potato in Peru. We conducted 2 randomized, multiple-meal studies in generally healthy, iron-depleted women of reproductive age. Malawian women (n = 24) received 400 g regular or biofortified sweetpotato test meals and Peruvian women (n = 35) received 500 g regular or biofortified potato test meals. Women consumed the meals at breakfast for 2 wk and were then crossed over to the other variety. We labeled the test meals with 57Fe or 58Fe and measured cumulative erythrocyte incorporation of the labels 14 d after completion of each test-meal sequence to calculate iron absorption. Iron absorption was compared by paired-sample t tests. The regular and biofortified orange-fleshed sweetpotato test meals contained 0.55 and 0.97 mg Fe/100 g. Geometric mean (95% CI) fractional iron absorption (FIA) was 5.82% (3.79%, 8.95%) and 6.02% (4.51%, 8.05%), respectively (P = 0.81), resulting in 1.9-fold higher total iron absorption (TIA) from biofortified sweetpotato (P < 0.001). The regular and biofortified potato test meals contained 0.33 and 0.69 mg Fe/100 g. FIA was 28.4% (23.5%, 34.2%) from the regular yellow-fleshed and 13.3% (10.6%, 16.6%) from the biofortified purple-fleshed potato meals, respectively (P < 0.001), resulting in no significant difference in TIA (P = 0.88). FIA from regular yellow-fleshed potato was remarkably high, at 28%. Iron absorbed from both potato test meals covered 33% of the daily absorbed iron requirement for women of reproductive age, while the biofortified orange-fleshed sweetpotato test meal covered 18% of this requirement. High polyphenol concentrations were likely the major inhibitors of iron absorption. These trials were registered at www.clinicaltrials.gov as NCT03840031 (Malawi) and NCT04216030 (Peru).
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影响因子：
4.3
作者：
Burgos, G.;Auqui, S.;Bonierbale, M.
通讯作者：
Bonierbale, M.
影响因子：
4.2
作者：
Erhardt, JG;Estes, JE;Craft, NE
通讯作者：
Craft, NE
影响因子：
6.1
作者：
Andre, Christelle M.;Oufir, Mouhssin;Larondelle, Yvan
通讯作者：
Larondelle, Yvan
影响因子：
4.2
作者：
Cercamondi, Colin I.;Egli, Ines M.;Hurrell, Richard F.
通讯作者：
Hurrell, Richard F.
影响因子：
20.3
作者：
Cook, JD;Boy, E;Daroca, MD
通讯作者：
Daroca, MD