High affinity allele for the gene of FCGR3A is risk factor for HIV infection and progression.
High affinity allele for the gene of FCGR3A is risk factor for HIV infection and progression.
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DOI：
10.1371/journal.pone.0015562
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发表时间：
2010-12-20
期刊：
影响因子：
3.7
通讯作者：
Pauza CD
中科院分区：
文献类型：
--
作者：
Poonia B;Kijak GH;Pauza CD
我们研究了Fc受体的遗传学，Fc受体作为免疫细胞上的活化受体发挥作用，并通过抗体介导的细胞毒性帮助控制HIV。因此，Fc受体可能对病毒免疫很重要，但也可能促进免疫超活化，从而增强感染。我们测量了两个Fc受体基因FCGR2A和FCGR3A中低活性和高活性等位基因的丰度，用于HIV疾病患者，天然病毒抑制剂（HIV+，无疾病）和健康对照，以显示基因型是否与感染和疾病相关。FCGR3A（158VV）高活性等位基因纯合子的个体主要在HIV进展者中发现，该组也倾向于V158变体的较高等位基因频率。与未感染的对照组相比，HIV阳性组（进展者和天然病毒抑制者）的V158等位基因频率显著较高。FCGR2A等位基因与HIV感染状态之间无明显相关性。我们的研究结果表明，FCGR3A的高活性等位基因可能是HIV感染或进展的危险因素，我们需要了解等位基因变异如何影响病毒控制和免疫激活之间的平衡。
We investigated the genetics of Fc receptors, which function as activating receptors on immune cells and help to control HIV through antibody-mediated cellular cytotoxicity. Thus, Fc receptors may be important for virus immunity but might also promote immune hyperactivation that would enhance infection. We measured abundance of low and high activity alleles in two Fc receptor genes, FCGR2A and FCGR3A, for persons with HIV disease, natural virus suppressors (HIV+, without disease) and healthy controls to show whether genotypes were associated with infection and disease. Individuals homozygous for the high activity allele of FCGR3A (158VV) were predominantly found among HIV progressors and this group was also skewed toward higher allele frequencies for the V158 variant. Both of the HIV positive groups (progressors and natural virus suppressors) had significantly higher frequencies of the V158 allele compared with uninfected controls. There were no apparent associations among FCGR2A alleles and HIV status. Our results indicate that high activity alleles of FCGR3A may be risk factors for HIV infection or progression and we need to understand how allelic variants affect the balance between virus control and immune activation.
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影响因子：
4.4
作者：
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通讯作者：
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影响因子：
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DOI：
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