Mortality-related risk factors of COVID-19: a systematic review and meta-analysis of 42 studies and 423,117 patients.
Mortality-related risk factors of COVID-19: a systematic review and meta-analysis of 42 studies and 423,117 patients.
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DOI：
10.1186/s12879-021-06536-3
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发表时间：
2021-08-21
影响因子：
3.7
通讯作者：
Zewotir T
中科院分区：
文献类型：
--
作者：
Dessie ZG;Zewotir T
冠状病毒病死亡率-2019年(新冠肺炎)在全球持续上升。几个风险因素对冠状病毒死亡率的影响以前曾在几项荟萃分析中报道过，但由于样本量较小。在这项系统性综述中，我们的目标是利用大量研究的大型数据集，总结现有关于新冠肺炎并发症、并发症、吸烟状况、肥胖、性别、年龄和D-二聚体与死亡风险之间关系的研究结果。计算机检索谷歌学者数据库、Cochrane图书馆、Web of Science(WOS)、EMbase、Medline/PubMed、新冠肺炎研究数据库和Scope us，检索时间截止至2020年8月31日。我们纳入了所有的人类研究，不分语言、发表日期或地区。共有42项研究，共有423,117名患者符合纳入标准。为了汇集估计，使用了混合效应模型。此外，还对发表偏倚和敏感性分析进行了评估。纳入的研究结果表明，合并症、性别、年龄、吸烟状况、肥胖、急性肾损伤和D-二聚体作为增加高级医疗护理需求的风险因素的贡献是一致的。分析结果表明，新冠肺炎住院患者死亡率为17.62%(95%可信区间为14.26~21.57%，42篇研究和423,117例患者)。年龄越大，死于冠状病毒的风险越高，合并优势比(POR)和危险比(PhR)分别为2.61(95%可信区间1.75~3.47)和1.31(95%可信区间1.11~1.51)。新冠肺炎死亡率与男性(POR = 1.45；95%CI 1.41~1.51；PhR = 1.24；95%CI 1.07~1.41)和当前吸烟者(POR = 1.42；95%CI 1.01~1.83)显著相关。此外，住院的新冠肺炎患者的死亡风险受到慢性阻塞性肺疾病、心血管疾病、糖尿病、高血压、肥胖、癌症、急性肾损伤和D-二聚体升高的患者的高度影响。慢性合并症、并发症和人口统计学变量，包括急性肾损伤、COPD、糖尿病、高血压、心血管疾病、癌症、D-二聚体增加、男性、老年、当前吸烟者和肥胖是与冠状病毒相关的致命后果的临床危险因素。这一发现可用于疾病未来的研究、控制和预防。
Mortality rates of coronavirus disease-2019 (COVID-19) continue to rise across the world. The impact of several risk factors on coronavirus mortality has been previously reported in several meta‐analyses limited by small sample sizes. In this systematic review, we aimed to summarize available findings on the association between comorbidities, complications, smoking status, obesity, gender, age and D-dimer, and risk of mortality from COVID-19 using a large dataset from a number of studies. Electronic databases including Google Scholar, Cochrane Library, Web of Sciences (WOS), EMBASE, Medline/PubMed, COVID-19 Research Database, and Scopus, were systematically searched till 31 August 2020. We included all human studies regardless of language, publication date or region. Forty-two studies with a total of 423,117 patients met the inclusion criteria. To pool the estimate, a mixed-effect model was used. Moreover, publication bias and sensitivity analysis were evaluated. The findings of the included studies were consistent in stating the contribution of comorbidities, gender, age, smoking status, obesity, acute kidney injury, and D-dimer as a risk factor to increase the requirement for advanced medical care. The analysis results showed that the pooled prevalence of mortality among hospitalized patients with COVID-19 was 17.62% (95% CI 14.26–21.57%, 42 studies and 423,117 patients). Older age has shown increased risk of mortality due to coronavirus and the pooled odds ratio (pOR) and hazard ratio (pHR) were 2.61 (95% CI 1.75–3.47) and 1.31 (95% CI 1.11–1.51), respectively. A significant association were found between COVID-19 mortality and male (pOR = 1.45; 95% CI 1.41–1.51; pHR = 1.24; 95% CI 1.07–1.41), and current smoker (pOR = 1.42; 95% CI 1.01–1.83). Furthermore, risk of mortality among hospitalized COVID-19 patients is highly influenced by patients with Chronic Obstructive Pulmonary Disease (COPD), Cardiovascular Disease (CVD), diabetes, hypertension, obese, cancer, acute kidney injury and increase D-dimer. Chronic comorbidities, complications, and demographic variables including acute kidney injury, COPD, diabetes, hypertension, CVD, cancer, increased D-dimer, male gender, older age, current smoker, and obesity are clinical risk factors for a fatal outcome associated with coronavirus. The findings could be used for disease’s future research, control and prevention.
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影响因子：
32.4
作者：
Goronzy JJ;Weyand CM
通讯作者：
Weyand CM
影响因子：
1.8
作者：
Barman, Hasan Ali;Atici, Adem;Gungor, Baris
通讯作者：
Gungor, Baris
DOI：
10.1590/1806-9282.66.12.1679
发表时间：
2020-12-01
期刊：
Revista da Associação Médica Brasileira
影响因子：
--
作者：
Caliskan, Tayfun;Saylan, Bengu
通讯作者：
Saylan, Bengu
影响因子：
3.1
作者：
Chilimuri, Sridhar;Sun, Haozhe;Nayudu, Suresh K.
通讯作者：
Nayudu, Suresh K.
影响因子：
5.1
作者：
Albitar, Orwa;Ballouze, Rama;Ghadzi, Siti Maisharah Sheikh
通讯作者：
Ghadzi, Siti Maisharah Sheikh