Cellular basis of learning and memory in the carotid body.
Cellular basis of learning and memory in the carotid body.
复制标题
DOI：
10.3389/fnsyn.2022.902319
复制
发表时间：
2022
影响因子：
3.7
通讯作者：
Paton, Julian F. R.
中科院分区：
文献类型：
--
作者：
Gold, Olivia M. S.;Bardsley, Emma N. N.;Ponnampalam, Anna P. P.;Pauza, Audrys G. G.;Paton, Julian F. R.
颈动脉体是人体主要的外周化学感受器，在缺氧时对呼吸和心血管调节至关重要。然而，现在有大量证据表明颈动脉体是一个多模态传感器，介导多种生理反应的化学反射，包括pH值、温度、酸中毒以及激素、葡萄糖和免疫调节。颈动脉体如何检测并启动对这些不同刺激的适当生理反应？答案可能在于颈动脉本身的结构。我们认为，在器官水平上，颈动脉体相当于一个微型大脑，具有由神经递质表达和受体谱定义的簇状血管球细胞划分的离散区域，并与定义的反射弧相连，反射弧在启动不同的生理反应中起关键作用，在许多方面类似于连接特定输入和选择输出的交换机。同样，在中枢神经系统内，特定的生理结果通过不同的神经元连接信号进行协调。与大脑一样，我们认为高度有组织的细胞连接对于调节颈动脉体对给定刺激的协调输出至关重要。此外，突触可塑性、学习和记忆的基本组成部分似乎在颈动脉体中得到保存，包括谷氨酸和gaba能系统的存在，证据表明颈动脉体常见疾病的病理生理可能与这些过程的偏差有关。几十年的研究促进了我们对中枢神经系统在健康和疾病中的理解，我们讨论了理解涉及神经元功能障碍和突触活动的关键过程可能转化为颈动脉体，为治疗创新提供新的见解和途径。
The carotid body is the primary peripheral chemoreceptor in the body, and critical for respiration and cardiovascular adjustments during hypoxia. Yet considerable evidence now implicates the carotid body as a multimodal sensor, mediating the chemoreflexes of a wide range of physiological responses, including pH, temperature, and acidosis as well as hormonal, glucose and immune regulation. How does the carotid body detect and initiate appropriate physiological responses for these diverse stimuli? The answer to this may lie in the structure of the carotid body itself. We suggest that at an organ-level the carotid body is comparable to a miniature brain with compartmentalized discrete regions of clustered glomus cells defined by their neurotransmitter expression and receptor profiles, and with connectivity to defined reflex arcs that play a key role in initiating distinct physiological responses, similar in many ways to a switchboard that connects specific inputs to selective outputs. Similarly, within the central nervous system, specific physiological outcomes are co-ordinated, through signaling via distinct neuronal connectivity. As with the brain, we propose that highly organized cellular connectivity is critical for mediating co-ordinated outputs from the carotid body to a given stimulus. Moreover, it appears that the rudimentary components for synaptic plasticity, and learning and memory are conserved in the carotid body including the presence of glutamate and GABAergic systems, where evidence pinpoints that pathophysiology of common diseases of the carotid body may be linked to deviations in these processes. Several decades of research have contributed to our understanding of the central nervous system in health and disease, and we discuss that understanding the key processes involved in neuronal dysfunction and synaptic activity may be translated to the carotid body, offering new insights and avenues for therapeutic innovation.
登录
查看更多内容
DOI：
10.1016/j.bbrc.2004.07.081
发表时间：
2004-09-10
影响因子：
3.1
作者：
Buttigieg, J;Nurse, CA
通讯作者：
Nurse, CA
影响因子：
--
作者：
BARON, M;EYZAGUIRRE, C
通讯作者：
EYZAGUIRRE, C
DOI：
10.1161/hypertensionaha.118.10844
发表时间：
2018-06
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Bardsley EN;Davis H;Buckler KJ;Paterson DJ
通讯作者：
Paterson DJ
影响因子：
2.9
作者：
Behuet, Sabrina;Cremer, Jennifer Nadine;Amunts, Katrin
通讯作者：
Amunts, Katrin
动脉化学感受器中的任务通道及其在氧气和酸感应中的作用。
DOI：
10.1007/s00424-015-1689-1
发表时间：
2015-05
期刊：
Pflugers Archiv : European journal of physiology
影响因子：
--
作者：
Buckler KJ
通讯作者：
Buckler KJ