Correlation of X-ray diffraction signatures of breast tissue and their histopathological classification.
Correlation of X-ray diffraction signatures of breast tissue and their histopathological classification.
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DOI：
10.1038/s41598-017-13399-9
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发表时间：
2017-10-11
影响因子：
4.6
通讯作者：
Vinnicombe SJ
中科院分区：
文献类型：
--
作者：
Moss RM;Amin AS;Crews C;Purdie CA;Jordan LB;Iacoviello F;Evans A;Speller RD;Vinnicombe SJ
本试验研究了X射线衍射（XRD）测量与乳腺组织组织病理学分析的相关性。研究了8个乳腺癌样本。每个样本都含有正常组织和癌组织的混合物。总共在样品的不同位置进行了522次单独的XRD测量（总共8次）。对所得XRD光谱进行主成分分析（PCA），以确定是否存在可用于识别不同组织成分的任何区别特征。前两个主成分（PC）可描述谱图间99.0%的变异。将PC空间中的点的位置与通过组织病理学确定的分类进行比较，表明XRD光谱的形状/幅度与组织类型之间的相关性。这些结果是令人鼓舞的，并表明XRD可用于术中或术后分类的散装组织样本。
This pilot study examines the correlation of X-ray diffraction (XRD) measurements with the histopathological analysis of breast tissue. Eight breast cancer samples were investigated. Each sample contained a mixture of normal and cancerous tissues. In total, 522 separate XRD measurements were made at different locations across the samples (8 in total). The resulting XRD spectra were subjected to principal component analysis (PCA) in order to determine if there were any distinguishing features that could be used to identify different tissue components. 99.0% of the variation between the spectra were described by the first two principal components (PC). Comparing the location of points in PC space with the classification determined by histopathology indicated correlation between the shape/magnitude of the XRD spectra and the tissue type. These results are encouraging and suggest that XRD could be used for the intraoperative or postoperative classification of bulk tissue samples.
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影响因子：
2.4
作者：
Kern, Katie;Peerzada, Lubna;MacDonald, Carolyn
通讯作者：
MacDonald, Carolyn
影响因子：
2.4
作者：
Lakshmanan, Manu N.;Greenberg, Joel A.;Kapadia, Anuj J.
通讯作者：
Kapadia, Anuj J.
影响因子：
1.3
作者：
Moss, Robert;Crews, Chiaki;Speller, Robert
通讯作者：
Speller, Robert
影响因子：
1.6
作者：
Pani, S.;Cook, E. J.;Speller, R. D.
通讯作者：
Speller, R. D.
影响因子：
5.9
作者：
Scott, Robert;Stone, Nicholas;Rogers, Keith
通讯作者：
Rogers, Keith