High resolution CBV assessment with PEAK‐EPI: k‐t‐undersampling and reconstruction in echo planar imaging
High resolution CBV assessment with PEAK‐EPI: k‐t‐undersampling and reconstruction in echo planar imaging
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使用 PEAKâEPI 进行高分辨率 CBV 评估：回波平面成像中的 kâtâ 欠采样和重建
DOI：
10.1002/mrm.26298
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发表时间：
2017
影响因子：
3.3
通讯作者：
M. Zaitsev
中科院分区：
文献类型：
--
作者：
I. Mader;B. Jung;J. Hennig;M. Zaitsev
目的在基于回声平面成像(EPI)的动态磁化率对比加权脑血流灌注测量中，获得更高的空间分辨率和更好的脑覆盖率，同时减少平面内磁化率伪影。基于翻转角变化引起的动态特性，对每种方法的性能进行了分析，评估了时间保真度、时间信噪比和g因子。所有方法都与传统的GRAPPA重建进行了比较。然后，在6名患者中，使用两个半剂量动态磁化率对比加权脑血流灌注测量，将具有就地自动校准信号ATR= 5的峰-EPI与标准的临床EPI方案进行比较。结果PEAK-EPI的采集促进了空间分辨率的显著提高，并且与传统的GRAPPA相比，提供了更好的信噪比。观察到所得到的重建质量高度依赖于自动校准信号采集的类型。结论所获得的高分辨率脑血容量图比相应的标准EPI图显示了更详细的信息，有利于肿瘤组织的详细勾画。Magn Reson Med 77：2153-2166,2017。2016年国际核磁共振医学学会
PurposeAchieving higher spatial resolution and improved brain coverage while mitigating in‐plane susceptibility artifacts in the assessment of perfusion parameters, such as cerebral blood volume, in echo planar imaging (EPI)‐based dynamic susceptibility contrast weighted cerebral perfusion measurements.MethodsPEAK‐EPI, an EPI sequence with interleaved readout trajectories and three different strategies for autocalibration‐signal acquisition (inplace,dynamic extraandextra) is presented. Performance of each approach is analyzedin vivobased on flip angle variation induced dynamics, assessing temporal fidelity, temporal SNR and g‐factors. All approaches are compared with conventional GRAPPA reconstructions. PEAK‐EPI with inplace autocalibration‐signal atR= 5 is then compared with the standard clinical EPI protocol in six patients, using two half‐dose dynamic susceptibility contrast weighted cerebral perfusion measurements per subject.ResultsPEAK‐EPI acquisition facilitates a substantial increase of spatial resolution at a higher number of slices per TR and provides improved SNR compared to conventional GRAPPA. High dependency of the resulting reconstruction quality on the type of autocalibration‐signal acquisition is observed. PEAK‐EPI with inplace autocalibration‐signal achieves high temporal fidelity and initial feasibility is shown.ConclusionThe obtained high resolution cerebral blood volume maps reveal more detailed information than in corresponding standard EPI measurements and facilitate detailed delineation of tumorous tissue. Magn Reson Med 77:2153–2166, 2017. © 2016 International Society for Magnetic Resonance in Medicine
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影响因子：
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