The effects of Parkinson's disease and age on syncopated finger movements.
The effects of Parkinson's disease and age on syncopated finger movements.
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DOI：
10.1016/j.brainres.2009.06.099
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发表时间：
2009-09-22
期刊：
影响因子：
2.9
通讯作者：
Mackinnon CD
中科院分区：
文献类型：
--
作者：
Stegemöller EL;Simuni T;Mackinnon CD
在年轻健康的成年人中，切分手指运动（连续节拍之间的运动）的特征在于运动速率接近2 Hz时的频率依赖性相位变化。在健康的年轻人中，在双手反相（不对称）任务期间观察到类似的频率依赖性相变，但这种转变频率在帕金森病（PD）患者和老年人中显着降低。到目前为止，没有研究已经检查了过渡频率与单手切分运动的PD患者或老年人。本研究检查了运动频率对PD患者、与PD患者匹配的老年受试者和年轻受试者的无约束切分食指屈曲运动性能的影响。切分动作由频率以0.25 Hz增量从1 Hz增加到3 Hz的声学音调进行起搏。对运动时相进行量化，并比较两组受试者从切分过渡到同步的运动频率。主要发现是PD患者在停药时进行切分运动的能力明显受损。药物治疗并没有显著改善表现。此外，老年受试者的转换频率低于年轻受试者。这些研究结果表明，与双手任务相似，与单手切分手指运动相关的协调动力学从稳定模式过渡到不稳定模式，PD患者和老年人的频率明显低于年轻人。
In young healthy adults, syncopated finger movements (movements between consecutive beats) are characterized by a frequency-dependent change in phase at movement rates near 2 Hz. A similar frequency-dependent phase transition is observed during bimanual anti-phase (asymmetric) tasks in healthy young adults, but this transition frequency is significantly lowered in both patients with Parkinson's disease (PD) and older adults. To date, no study has examined the transition frequency associated with unimanual syncopated movements in patients with PD or older adults. This study examined the effects of movement frequency on the performance of unconstrained syncopated index finger flexion movements in patients with PD, older adult subjects matched to patients with PD, and young adult subjects. Syncopated movements were paced by an acoustic tone that increased in frequency from 1 to 3 Hz in 0.25 Hz increments. Movement phase was quantified and the movement frequency where subjects transitioned from syncopation to synchronization was compared between groups. The principal finding was a marked impairment in the ability of patients with PD to perform syncopated movements when off medication. Medication did not significantly improve performance. In addition, the transition frequency for older adult subjects was lower than young adult subjects. These findings demonstrate that, similar to bimanual tasks, the coordination dynamics associated with unimanual syncopated finger movements transition from a stable to an unstable pattern at significantly lower frequencies in patients with PD and older adults compared to young adults.
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