Dynamic determination of oxygenation and lung compliance in murine pneumonectomy.
Dynamic determination of oxygenation and lung compliance in murine pneumonectomy.
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DOI：
10.3109/01902148.2011.561399
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发表时间：
2011-06
影响因子：
1.7
通讯作者：
Mentzer SJ
中科院分区：
文献类型：
--
作者：
Gibney BC;Lee GS;Houdek JP;Lin M;Miele LF;Chamoto K;Konerding MA;Tsuda A;Mentzer SJ
小鼠胸外科手术已被应用于广泛的调查，但很少有人知道小鼠的生理反应肺手术。采用连续动脉血氧饱和度监测和呼吸机，我们研究了麻醉和肺切除术对小鼠氧饱和度和肺力学的影响。镇静导致氧饱和度呈剂量依赖性下降，范围为55- 82%。通过增加速率和潮气量的机械通气恢复氧饱和度。在所研究的小鼠品系中，最佳的呼吸速率为200次/分钟，潮气量为10 ml/kg。持续的充气压力，被称为“复张策略”，改善了肺容量、肺顺应性和动脉氧合。相反，呼气末正压（PEEP）对氧合有不利影响;这种影响在肺切除术后得到改善。我们的研究结果证实，小鼠的肺容量是动态确定的，并建议机械通气的阈值水平，以维持围手术期的氧饱和度。
Thoracic surgical procedures in mice have been applied to a wide range of investigations, but little is known about the murine physiologic response to pulmonary surgery. Using continuous arterial oximetry monitoring and the FlexiVent murine ventilator, we investigated the effect of anesthesia and pneumonectomy on mouse oxygen saturation and lung mechanics. Sedation resulted in a dose-dependent decline of oxygen saturation that ranged from 55–82%. Oxygen saturation was restored by mechanical ventilation with increased rate and tidal volumes. In the mouse strain studied, optimal ventilatory rates were a rate of 200/minute and a tidal volume of 10ml/kg. Sustained inflation pressures, referred to as a "recruitment maneuver," improved lung volumes, lung compliance and arterial oxygenation. In contrast, positive end expiratory pressure (PEEP) had a detrimental effect on oxygenation; an effect that was ameliorated after pneumonectomy. Our results confirm that lung volumes in the mouse are dynamically determined and suggest a threshold level of mechanical ventilation to maintain perioperative oxygen saturation.
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DOI：
10.1165/rcmb.2005-0092oc
发表时间：
2005-12-01
影响因子：
6.4
作者：
Mae, M;O'Connor, TP;Crystal, RG
通讯作者：
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影响因子：
3.3
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影响因子：
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影响因子：
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作者：
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