Early trauma and increased risk for physical aggression during adulthood: the moderating role of MAOA genotype.
Early trauma and increased risk for physical aggression during adulthood: the moderating role of MAOA genotype.
复制标题
早期创伤和成年期间身体攻击的风险增加：MAOA基因型的调节作用。
DOI：
10.1371/journal.pone.0000486
复制
发表时间：
2007-05-30
期刊：
影响因子：
3.7
通讯作者：
Troisi, Alfonso
中科院分区：
文献类型：
--
作者：
Frazzetto, Giovanni;Di Lorenzo, Giorgio;Carola, Valeria;Proietti, Luca;Sokolowska, Ewa;Siracusano, Alberto;Gross, Cornelius;Troisi, Alfonso
以前的研究报道，单胺氧化酶A(MAOA)基因启动子的功能多态性可以缓和早年生活逆境与暴力和反社会行为风险增加之间的关联。在这项对精神科门诊患者和健康志愿者(N MAOA235)的联合人群研究中，我们测试了这样一种假设，即 = 基因在人生头15年经历的早期创伤生活事件与成年后身体攻击行为之间的关联是由攻击性问卷评估的。将性别、早期创伤暴露和MAOA型作为受试者间因素的单因素方差分析模型显示MAOAXETLE(F1,227 = 8.20，P = 0.005)和性别×MAOAXETLE(F1,227 = 7.04，P = 0.009)交互作用显著。身体攻击得分在经历过早期创伤性生活事件和携带MAOA活性低的等位基因(MAOA-L)的男性中更高。我们在健康志愿者亚组(N = 145)中重复了这一分析，以排除观察到的G×E相互作用是由于我们的样本中包括精神疾病患者，并且不能推广到一般人群。健康志愿者小组的结果与整个样本的结果相同。用涉及MAOA多态的ANOVA效应解释的身体攻击分数的累积变异在整个样本中为6.6%，在健康志愿者的子样本中为12.1%。我们的结果支持这样一种假设，即当与早期创伤性生活事件相结合时，低MAOA活动是成年期间攻击行为的重要危险因素，并表明在MAOA相关攻击研究中，关注攻击行为方面的维度测量的使用可能增加发现显著的基因与环境交互作用的可能性。
Previous research has reported that a functional polymorphism in the monoamine oxidase A (MAOA) gene promoter can moderate the association between early life adversity and increased risk for violence and antisocial behavior. In this study of a combined population of psychiatric outpatients and healthy volunteers (N = 235), we tested the hypothesis that MAOA genotype moderates the association between early traumatic life events (ETLE) experienced during the first 15 years of life and the display of physical aggression during adulthood, as assessed by the Aggression Questionnaire. An ANOVA model including gender, exposure to early trauma, and MAOA genotype as between-subjects factors showed significant MAOA×ETLE (F1,227 = 8.20, P = 0.005) and gender×MAOA×ETLE (F1,227 = 7.04, P = 0.009) interaction effects. Physical aggression scores were higher in men who had experienced early traumatic life events and who carried the low MAOA activity allele (MAOA-L). We repeated the analysis in the subgroup of healthy volunteers (N = 145) to exclude that the observed G×E interactions were due to the inclusion of psychiatric patients in our sample and were not generalizable to the population at large. The results for the subgroup of healthy volunteers were identical to those for the entire sample. The cumulative variance in the physical aggression score explained by the ANOVA effects involving the MAOA polymorphism was 6.6% in the entire sample and 12.1% in the sub-sample of healthy volunteers. Our results support the hypothesis that, when combined with exposure to early traumatic life events, low MAOA activity is a significant risk factor for aggressive behavior during adulthood and suggest that the use of dimensional measures focusing on behavioral aspects of aggression may increase the likelihood of detecting significant gene-by-environment interactions in studies of MAOA-related aggression.
登录
查看更多内容
影响因子：
10.6
作者：
Huizinga, David;Haberstick, Brett C.;Hewitt, John K.
通讯作者：
Hewitt, John K.
影响因子：
4.8
作者：
Chen, Kevin;Cases, Olivier;Shih, Jean Chen
通讯作者：
Shih, Jean Chen
影响因子：
--
作者：
Feinberg, Mark E.;Button, Tanya M. M.;Hetherington, E. Mavis
通讯作者：
Hetherington, E. Mavis
影响因子：
56.9
作者：
Caspi, A;McClay, J;Poulton, R
通讯作者：
Poulton, R
影响因子：
--
作者：
Johnson, JG;Cohen, P;Bernstein, DP
通讯作者：
Bernstein, DP