What to feed or what not to feed-that is still the question.
What to feed or what not to feed-that is still the question.
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DOI：
10.1007/s11306-021-01855-7
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发表时间：
2021-11-20
期刊：
影响因子：
--
通讯作者：
Boros LG
中科院分区：
文献类型：
--
作者：
Lech JC;Dorfsman SI;Répás Z;Krüger TPJ;Gyalai IM;Boros LG
本文综述了用人工全混合日粮（TMR）代替传统牧草饲喂牛后的代谢紊乱。确定在牛奶和肉类生产过程中，谷物喂养如何损害回补线粒体基质的氘消耗功能。基于已发表的数据，我们在此评估了谷物喂养的动物如何基本上遵循基于支链氨基酸和奇数链脂肪酸的还原性羧化依赖性原料，这也是人类癌症中线粒体氘积累功能障碍之一。现在很明显，基于食物的细胞内氘交换反应，特别是糖原底物氧化的反应，是富氘（2 H; D）代谢水的重要来源，对动物和人类健康具有显著影响。高氘营养乳制品在人体内氧化后燃烧成代谢水可能导致与现有技术水平的奶牛文章中描述的代谢状况和疾病相似的代谢状况和疾病。谷物饲喂也限制了氧输送到线粒体，以通过暴露于TMR成分的转基因作物中使用的草甘膦除草剂来有效地产生氘耗尽的代谢水。医学代谢组学、生物化学和氘组学（生物氘分馏和鉴别的科学）的发展需要进行紧急的批判性审查，以便通过彻底了解谷物喂养奶牛的代谢健康受损如何影响人类消费者来控制糖尿病、肥胖症和癌症等人群疾病的流行病学规模。
This review addresses metabolic diversities after grain feeding of cattle using artificial total mixed ration (TMR), in place of pasture-based feeding. To determine how grain feeding impairs the deuterium-depleting functions of the anaplerotic mitochondrial matrix during milk and meat production. Based on published data we herein evaluate how grain-fed animals essentially follow a branched-chain amino acid and odd-chain fatty acid-based reductive carboxylation-dependent feedstock, which is also one of the mitochondrial deuterium-accumulating dysfunctions in human cancer. It is now evident that food-based intracellular deuterium exchange reactions, especially that of glycogenic substrate oxidation, are significant sources of deuterium-enriched (2H; D) metabolic water with a significant impact on animal and human health. The burning of high deuterium nutritional dairy products into metabolic water upon oxidation in the human body may contribute to similar metabolic conditions and diseases as described in state-of-the-art articles for cows. Grain feeding also limits oxygen delivery to mitochondria for efficient deuterium-depleted metabolic water production by glyphosate herbicide exposure used in genetically modified crops of TMR constituents. Developments in medical metabolomics, biochemistry and deutenomics, which is the science of biological deuterium fractionation and discrimination warrant urgent critical reviews in order to control the epidemiological scale of population diseases such as diabetes, obesity and cancer by a thorough understanding of how the compromised metabolic health of grain-fed dairy cows impacts human consumers.
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影响因子：
4.3
作者：
Bailey DC;Todt CE;Burchfield SL;Pressley AS;Denney RD;Snapp IB;Negga R;Traynor WL;Fitsanakis VA
通讯作者：
Fitsanakis VA
影响因子：
7.3
作者：
Schleucher, J;Vanderveer, P;Sharkey, TD
通讯作者：
Sharkey, TD
影响因子：
3.9
作者：
URBAUER, JL;DORGAN, LJ;SCHUSTER, SM
通讯作者：
SCHUSTER, SM
影响因子：
8.8
作者：
Mullen AR;Hu Z;Shi X;Jiang L;Boroughs LK;Kovacs Z;Boriack R;Rakheja D;Sullivan LB;Linehan WM;Chandel NS;DeBerardinis RJ
通讯作者：
DeBerardinis RJ
影响因子：
3.3
作者：
Mahar R;Zeng H;Giacalone A;Ragavan M;Mareci TH;Merritt ME
通讯作者：
Merritt ME