Genetic and environmental sources of covariation between early drinking and adult functioning.
Genetic and environmental sources of covariation between early drinking and adult functioning.
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DOI：
10.1037/adb0000283
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发表时间：
2017-08
期刊：
影响因子：
--
通讯作者：
Iacono WG
中科院分区：
文献类型：
--
作者：
Waldron JS;Malone SM;McGue M;Iacono WG
绝大多数人在青春期第一次开始饮酒。鉴于其使用的广泛性以及有证据表明青少年可能特别容易受到其影响，人们担心青少年饮酒对成人功能的长期有害影响。虽然一些研究人员认为遗传过程可能会混淆这种关系，但饮酒和后来的调整之间的联系机制仍不清楚。目前的研究利用遗传信息样本和生物识别模型来检查家族对这种关联的影响的性质，并确定遗传混杂的可能性。样本取自明尼苏达双胞胎家庭研究，这是一项纵向研究，由 2,764 名双胞胎组成，对 17 岁至 29 岁（老年队列）或 11 至 29 岁（年轻队列）的两个队列进行定期随访评估。广泛的成人指标包括评估药物使用、反社会行为、个性、社会经济地位和社会功能。使用双变量 Cholesky 分解来研究遗传和环境对青少年饮酒的常见影响以及成人调整的每项措施。结果表明，遗传因素和非共享环境影响通常是解释青少年饮酒与以后功能之间关系的最重要因素。虽然非共享环境影响的存在与青少年饮酒的因果影响并不矛盾，但研究结果表明，与青少年饮酒相关的许多调整问题最好理解为受遗传影响的脆弱性。
The vast majority of individuals initiate alcohol consumption for the first time in adolescence. Given the widespread nature of its use and evidence that adolescents may be especially vulnerable to its effects, there is concern about the long-term detrimental impact of adolescent drinking on adult functioning. While some researchers have suggested that genetic processes may confound the relationship, the mechanisms linking drinking and later adjustment remain unclear. The current study utilized a genetically-informed sample and biometric modeling to examine the nature of the familial influences on this association and identify the potential for genetic confounding. The sample was drawn from the Minnesota Twin Family Study, a longitudinal study consisting of 2,764 twins assessed in two cohorts at regular follow-ups from age 17 to age 29 (older cohort) or age 11 to age 29 (younger cohort). A broad range of adult measures was included assessing substance use, antisocial behavior, personality, socioeconomic status, and social functioning. A bivariate Cholesky decomposition was used to examine the common genetic and environmental influences on adolescent drinking and each of the measures of adult adjustment. The results revealed that genetic factors and non-shared environmental influences were generally most important in explaining the relationship between adolescent drinking and later functioning. While the presence of non-shared environmental influences on the association are not inconsistent with a causal impact of adolescent drinking, the findings suggest that many of the adjustment issues associated with adolescent alcohol consumption are best understood as genetically-influenced vulnerabilities.
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DOI：
10.1002/ajmg.b.32010
发表时间：
2012-01
影响因子：
2.8
作者：
Althoff, Robert R.;Hudziak, James J.;Willemsen, Gonneke;Hudziak, Vicenta;Bartels, Meike;Boomsma, Dorret I.
通讯作者：
Boomsma, Dorret I.
影响因子：
2.6
作者：
Hicks, Brian M.;Schalet, Benjamin D.;Malone, Stephen M.;Iacono, William G.;McGue, Matt
通讯作者：
McGue, Matt
影响因子：
2.6
作者：
Baker, LA;Treloar, SA;Martin, NG
通讯作者：
Martin, NG
影响因子：
3
作者：
Boker S;Neale M;Maes H;Wilde M;Spiegel M;Brick T;Spies J;Estabrook R;Kenny S;Bates T;Mehta P;Fox J
通讯作者：
Fox J
影响因子：
10.6
作者：
Grant, Julia D.;Agrawal, Arpana;Bucholz, Kathleen K.;Madden, Pamela A. F.;Pergadia, Michele L.;Nelson, Elliot C.;Lynskey, Michael T.;Todd, Richard D.;Todorov, Alexandre A.;Hansell, Narelle K.;Whitfield, John B.;Martin, Nicholas G.;Heath, Andrew C.
通讯作者：
Heath, Andrew C.