Imaging gold nanorods in excised human breast carcinoma by spectroscopic optical coherence tomography.

Imaging gold nanorods in excised human breast carcinoma by spectroscopic optical coherence tomography.
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DOI:
10.1039/b823389f
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发表时间:
2009-01-01
影响因子:
--
通讯作者:
Boppart SA
Boppart SA
中科院分区:
其他
文献类型:
--
作者:
Oldenburg AL;Hansen MN;Ralston TS;Wei A;Boppart SA

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等离子共振金纳米棒 (GNR) 可用作光谱光学相干断层扫描 (SOCT) 的成像剂。 GNR 的纵横比经过调整,可实现远红光的最大吸收,从而与近红外 SOCT 成像波段的低波长边缘产生部分光谱重叠。 GNR 的光谱吸收曲线被纳入深度分辨算法中,用于绘制 OCT 图像内的相对 GNR 密度。这项技术使我们能够对切除的人类乳腺癌中的 GNR 分布进行成像,证明它们在异质、高度分散的组织中作为 OCT 造影剂的潜力。
Plasmon-resonant gold nanorods (GNRs) can serve as imaging agents for spectroscopic optical coherence tomography (SOCT). The aspect ratio of the GNRs are adjusted for maximum absorption in the far red to create a partial spectral overlap with the low-wavelength edge of the near-infrared SOCT imaging band. The spectroscopic absorption profile of the GNRs is incorporated into a depth-resolved algorithm for mapping the relative GNR density within OCT images. This technique enables us to image GNR distributions in excised human breast carcinomas, demonstrating their potential as OCT contrast agents in heteregeneous, highly scattering tissues.
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