Late, not early mismatch responses to changes in frequency are reduced or deviant in children with dyslexia: an event-related potential study.
Late, not early mismatch responses to changes in frequency are reduced or deviant in children with dyslexia: an event-related potential study.
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DOI：
10.1186/1866-1955-6-21
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发表时间：
2014
影响因子：
4.9
通讯作者：
Bishop DV
中科院分区：
文献类型：
--
作者：
Halliday LF;Barry JG;Hardiman MJ;Bishop DV
口头和书面语言的发育障碍与听觉信息处理的缺陷有关。然而，研究结果一直不一致，无论是行为和电生理措施。在这项研究中，我们检查了20名6- 14岁的发展性阅读障碍儿童和20名年龄匹配的对照组的事件相关电位（ERP），分为年轻（6-11岁，n = 10）和老年（11-14岁，n = 10）年龄段。我们专注于早期（失配负性; MMN）和晚期（晚期判别负性; LDN）的传统失配反应和相关措施来自时间-频率分析（试验间的一致性和事件相关的频谱扰动）。使用听觉oddball任务引起反应，其中1000 Hz标准流与罕见的大（1,200 Hz）和小（1,030 Hz）频率偏差穿插。传统的分析显示，无论是大或小的频率偏差的MMN的大小组之间没有显着差异。然而，较年轻的年龄段的阅读障碍儿童表现出增强的试验间的连贯性，在θ频带的时间窗口对应的MMN小偏差。相比之下，这些相同的儿童表现出较小的偏差相对于他们的年龄匹配的控制，而阅读障碍的年龄较大的儿童表现出较短的时间和较低强度的事件相关的deserminization在这个时间窗口。阅读障碍儿童对听觉频率变化的初始检测和辨别能力正常甚至增强。相反，后期听觉处理的缺陷似乎是这一人群的一个特征。
Developmental disorders of oral and written language have been linked to deficits in the processing of auditory information. However, findings have been inconsistent, both for behavioural and electrophysiological measures. In this study, we examined event-related potentials (ERPs) in 20 6- to 14-year-old children with developmental dyslexia and 20 age-matched controls, divided into younger (6–11 years, n = 10) and older (11–14 years, n = 10) age bands. We focused on early (mismatch negativity; MMN) and late (late discriminative negativity; LDN) conventional mismatch responses and associated measures derived from time-frequency analysis (inter-trial coherence and event-related spectral perturbation). Responses were elicited using an auditory oddball task, whereby a stream of 1000-Hz standards was interspersed with rare large (1,200 Hz) and small (1,030 Hz) frequency deviants. Conventional analyses revealed no significant differences between groups in the size of the MMN to either large or small frequency deviants. However, the younger age band of children with dyslexia showed an enhanced inter-trial coherence in the theta frequency band over the time window corresponding to the MMN to small deviants. By contrast, these same children showed a reduced-amplitude LDN for the small deviants relative to their age-matched controls, whilst the older children with dyslexia showed a shorter and less intense period of event-related desynchronization over this time window. Initial detection and discrimination of auditory frequency change appears normal or even enhanced in children with dyslexia. Rather, deficits in late-stage auditory processing appear to be a feature of this population.
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影响因子：
3.7
作者：
Bishop DV;Hardiman MJ
通讯作者：
Hardiman MJ
影响因子：
2.4
作者：
Halliday, Lorna F.;Taylor, Jenny L.;Moore, David R.
通讯作者：
Moore, David R.
影响因子：
4.3
作者：
GATHERCOLE, SE;BADDELEY, AD
通讯作者：
BADDELEY, AD
影响因子：
3.7
作者：
Bishop, Dorothy V. M.;Hardiman, Mervyn;von Suchodoletz, Waldemar
通讯作者：
von Suchodoletz, Waldemar
影响因子：
3
作者：
Hamalainen, Jarmo A.;Salminen, Hanne K.;Leppanen, Paavo H. T.
通讯作者：
Leppanen, Paavo H. T.