Monitoring the blood coagulation process under various flow conditions with optical coherence tomography
Monitoring the blood coagulation process under various flow conditions with optical coherence tomography
复制标题
利用光学相干断层扫描监测各种血流条件下的血液凝固过程
DOI：
10.1117/1.jbo.19.4.046021
复制
发表时间：
2014-04
影响因子：
3.5
通讯作者：
Teng, Xiangshuai
中科院分区：
文献类型：
--
作者：
Xu, Xiangqun;Geng, Jinhai;Teng, Xiangshuai
抽象的。我们之前的工作证明光学相干断层扫描（OCT）技术能够表征全血凝固过程。从反射率与深度的关系曲线得出的 1/e 光穿透深度 (d1/e) 是为了检测静态下的全血凝固过程而开发的。为了考虑血流的影响，在本研究中，d1/e 与时间的关系是猪血液在模拟流动回路中循环，具有各种稳定层流，平均流速在 5 至 25mm/s 范围内。 d1/e的变化用于表示在不同血细胞比容(HCT)范围从25%到55%、速度从5到25mm/s、以及管道尺寸从0.9到2mm的情况下凝血过程中血液特性的变化。结果表明，凝血时间（tc）分别与 HCT、流速和管道尺寸呈正相关。此外，凝血率（Sr）随着HCT、流速和管道尺寸的增加而降低。这项研究证明，HCT、流速和管道尺寸是影响流动血液凝固过程中反向散射特性的重要因素。此外，OCT 有潜力以适当的参数代表流动的血液凝固过程。
Abstract. Our previous work demonstrated that an optical coherence tomography (OCT) technique was able to characterize the whole blood coagulation process. The 1/e light penetration depth (d1/e) derived from the profiles of reflectance versus depth was developed for detecting the whole blood coagulation process in static state. To consider the effect of blood flow, in the present study, d1/e versus time from the coagulating porcine blood circulated in a mock flow loop with various steady laminar flows at mean flow speed in the range from 5 to 25 mm/s. The variation of d1/e was used to represent the change of blood properties during coagulation in different hematocrits (HCT) ranging from 25% to 55%, velocities from 5 to 25 mm/s, and tubing sizes from 0.9 to 2 mm. The results showed that there were positive correlations between coagulation time (tc) and HCT, velocity, and tubing size, respectively. In addition, the coagulation rate (Sr) was decreased with the increase of HCT, velocity, and tubing size. This study testified that HCT, flow velocity, and tubing size were substantial factors affecting the backscattering properties during flowing blood coagulation. Furthermore, OCT has the potential to represent the process of flowing blood coagulation with proper parameters.
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DOI：
10.1098/rsta.2008.0109
发表时间：
2008-10
期刊：
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
影响因子：
--
作者：
S. G. Uzlova;Konstantin G. Guria;G. Guria
通讯作者：
S. G. Uzlova;Konstantin G. Guria;G. Guria
影响因子：
--
作者：
A. S. Douglas
通讯作者：
A. S. Douglas
影响因子：
2
作者：
Podoleanu AG
通讯作者：
Podoleanu AG
影响因子：
15.9
作者：
WEISS, HJ;TURITTO, VT;BAUMGARTNER, HR
通讯作者：
BAUMGARTNER, HR
影响因子：
3.6
作者：
Faber, DJ;Mik, EG;van Leeuwen, TG
通讯作者：
van Leeuwen, TG