Paediatric population neuroimaging and the Generation R Study: the second wave.
Paediatric population neuroimaging and the Generation R Study: the second wave.
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DOI：
10.1007/s10654-017-0319-y
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发表时间：
2018-01
影响因子：
13.6
通讯作者：
Tiemeier H
中科院分区：
文献类型：
--
作者：
White T;Muetzel RL;El Marroun H;Blanken LME;Jansen P;Bolhuis K;Kocevska D;Mous SE;Mulder R;Jaddoe VWV;van der Lugt A;Verhulst FC;Tiemeier H
儿科群体神经影像学是一个新兴的领域，福尔斯落在发展神经科学和流行病学之间的交叉点。群体神经影像学研究的一个关键特征是大规模招募，这是一般人群的代表。人群神经影像学的一种成功方法是将神经影像学研究嵌入大型流行病学队列。R世代研究是一项大型的、前瞻性的基于人群的出生队列研究，在2002年至2006年期间招募了近10，000名孕妇，并随着时间的推移对儿童及其父母进行了重复测量。磁共振成像在2009年被纳入，扫描了1070名6至9岁的儿童。第二波神经影像学检查于2013年4月启动，共有4245人访问MRI套件，4087名9至11岁儿童接受扫描。序列包括高分辨率结构MRI，35方向扩散加权成像，以及6分钟和2秒的静息状态功能MRI扫描。本文的目的是提供一个概述的成像协议和神经成像数据和元数据之间的重叠。最后，我们简要概述了我们的第一波神经影像学的结果，其中突出了一系列不同的问题，可以通过合并发展神经科学和流行病学领域来解决。本文的在线版本（doi：10.1007/s10654-017-0319-y）包含补充材料，可供授权用户使用。
Paediatric population neuroimaging is an emerging field that falls at the intersection between developmental neuroscience and epidemiology. A key feature of population neuroimaging studies involves large-scale recruitment that is representative of the general population. One successful approach for population neuroimaging is to embed neuroimaging studies within large epidemiological cohorts. The Generation R Study is a large, prospective population-based birth-cohort in which nearly 10,000 pregnant mothers were recruited between 2002 and 2006 with repeated measurements in the children and their parents over time. Magnetic resonance imaging was included in 2009 with the scanning of 1070 6-to-9-year-old children. The second neuroimaging wave was initiated in April 2013 with a total of 4245 visiting the MRI suite and 4087 9-to-11-year-old children being scanned. The sequences included high-resolution structural MRI, 35-direction diffusion weighted imaging, and a 6 min and 2 s resting-state functional MRI scan. The goal of this paper is to provide an overview of the imaging protocol and the overlap between the neuroimaging data and metadata. We conclude by providing a brief overview of results from our first wave of neuroimaging, which highlights a diverse array of questions that can be addressed by merging the fields of developmental neuroscience and epidemiology. The online version of this article (doi:10.1007/s10654-017-0319-y) contains supplementary material, which is available to authorized users.
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