Functionalized MoS2-erlotinib produces hyperthermia under NIR
Functionalized MoS2-erlotinib produces hyperthermia under NIR
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功能化MoS2-厄洛替尼在近红外下产生高温
DOI：
10.1186/s12951-019-0508-9
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发表时间：
2019-06
影响因子：
10.2
通讯作者：
Jia Lee
中科院分区：
文献类型：
--
作者：
Zhang Chen;Zhang Doudou;Liu Jian;Wang Jie;Lu Yusheng;Zheng Junxia;Li Bifei;Jia Lee
二硫化钼（MoS2）由于其出色的光热转换能力，在生物医学领域得到了广泛的应用。本文报道了一种基于mos2的新型多功能给药系统（MoS2-SS-HA）。通过用透明质酸（HA）修饰mos2纳米片，这些功能化的mos2纳米片已被开发成一种肿瘤靶向化疗纳米载体，用于近红外（NIR）光热触发的药物递送，促进化疗和光热治疗结合成一个癌症治疗系统。结果制备的纳米复合材料（MoS2-SS-HA）直径均匀（约125 nm），在生理溶液中具有良好的生物相容性和较高的稳定性，可以负载不溶性抗癌药物厄洛替尼（Er）。在近红外激光（NIR）照射下，Er的释放速度大大加快，表明该复合材料可以作为响应体系，通过近红外照射可以控制Er的释放。MTT实验和共聚焦成像结果表明，基于mos2的纳米平台可以选择性靶向并杀死cd44阳性肺癌细胞，特别是耐药细胞（A549和H1975）。体内肿瘤消融研究证明，与单独化疗或光热治疗相比，联合治疗具有更好的协同治疗效果。结论本研究开发的功能化mos2纳米平台可作为靶向给药和化学光热协同治疗肿瘤的有效系统。
BackgroundMolybdenum disulfide (MoS2) has been widely explored for biomedical applications due to its brilliant photothermal conversion ability. In this paper, we report a novel multifunctional MoS2-based drug delivery system (MoS2-SS-HA). By decorating MoS2nanosheets with hyaluronic acid (HA), these functionalized MoS2nanosheets have been developed as a tumor-targeting chemotherapeutic nanocarrier for near-infrared (NIR) photothermal-triggered drug delivery, facilitating the combination of chemotherapy and photothermal therapy into one system for cancer therapy.ResultsThe nanocomposites (MoS2-SS-HA) generated a uniform diameter (ca. 125 nm), exhibited great biocompatibility as well as high stability in physiological solutions, and could be loaded with the insoluble anti-cancer drug erlotinib (Er). The release of Er was greatly accelerated under near infrared laser (NIR) irradiation, showing that the composites can be used as responsive systems, with Er release controllable through NIR irradiation. MTT assays and confocal imaging results showed that the MoS2-based nanoplatform could selectively target and kill CD44-positive lung cancer cells, especially drug resistant cells (A549 and H1975). In vivo tumor ablation studies prove a better synergistic therapeutic effect of the joint treatment, compared with either chemotherapy or photothermal therapy alone.ConclusionThe functionalized MoS2nanoplatform developed in this work could be a potent system for targeted drug delivery and synergistic chemo-photothermal cancer therapy.
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影响因子：
5.3
作者：
通讯作者：
--
影响因子：
16.6
作者：
Chou, Stanley S.;Kaehr, Bryan;Kim, Jaemyung;Foley, Brian M.;De, Mrinmoy;Hopkins, Patrick E.;Huang, Jiaxing;Brinker, C. Jeffrey;Dravid, Vinayak P.
通讯作者：
Dravid, Vinayak P.
DOI：
10.1002/anie.201809753
发表时间：
2018-12-21
期刊：
Angewandte Chemie (International ed. in English)
影响因子：
--
作者：
Yang L;Sun H;Liu Y;Hou W;Yang Y;Cai R;Cui C;Zhang P;Pan X;Li X;Li L;Sumerlin BS;Tan W
通讯作者：
Tan W
影响因子：
10.8
作者：
Xiong, Feng;Wang, Haotian;Cui, Yi
通讯作者：
Cui, Yi
影响因子：
19
作者：
Ma, Yan;Liang, Xiaolong;Dai, Zhifei
通讯作者：
Dai, Zhifei