Self-Assembled Aptamer-Grafted Hyperbranched Polymer Nanocarrier for Targeted and Photoresponsive Drug Delivery.
Self-Assembled Aptamer-Grafted Hyperbranched Polymer Nanocarrier for Targeted and Photoresponsive Drug Delivery.
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DOI：
10.1002/anie.201809753
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发表时间：
2018-12-21
期刊：
影响因子：
--
通讯作者：
Tan W
中科院分区：
文献类型：
--
作者：
Yang L;Sun H;Liu Y;Hou W;Yang Y;Cai R;Cui C;Zhang P;Pan X;Li X;Li L;Sumerlin BS;Tan W
光响应材料由于其良好的时空选择性，成为精确控制药物释放的理想载体。然而，诸如缓慢释放动力学、固有毒性和缺乏靶向能力的缺点阻碍了它们转化为临床应用。本文构建了一种新型的DNA适配体接枝光响应性超支化聚合物，其可以自组装成纳米颗粒，从而实现生物相容性和靶向特异性，以及光可控释放行为。在紫外光照射下，观察到尼罗红负载的纳米颗粒由解组装引起的快速释放。进一步的体外细胞研究证实了这种递送系统的特异性结合和内化性能来自DNA适体冠。DOX纳米组装体对肿瘤细胞表现出选择性的光触发细胞毒性，表明其作为一种“智能”药物递送系统具有良好的治疗效果。
Photoresponsive materials are emerging as ideal carriers for precise controlled drug delivery owing to their high spatiotemporal selectivity. However, drawbacks such as slow release kinetics, inherent toxicity, and lack of targeting ability hinder their translation into clinical use. We herein constructed a new DNA aptamer-grafted photoresponsive hyperbranched polymer, which can self-assemble into nanoparticles, thereby achieving biocompatibility and target specificity, as well as light-controllable release behavior. Upon UV-irradiation, rapid release induced by disassembly was observed for Nile Red-loaded nanoparticles. Further in vitro cell studies confirmed this delivery system’s specific binding and internalization performance arising from the DNA aptamer corona. The DOX-loaded nanoassembly exhibited selective phototriggered cytotoxicity towards cancer cells, indicating its promising therapeutic effect as a “smart” drug delivery system.
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