Metabolic Properties of Lowdensity Lipoprotein (LDL) Triglycerides in Patients with Type 2 Diabetes, Comparison with Small Dense LDL-Cholesterol.
Metabolic Properties of Lowdensity Lipoprotein (LDL) Triglycerides in Patients with Type 2 Diabetes, Comparison with Small Dense LDL-Cholesterol.
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DOI：
10.5551/jat.62789
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发表时间：
2022-05-01
影响因子：
4.4
通讯作者：
Ito, Yasuki
中科院分区：
文献类型：
--
作者：
Hirano, Tsutomu;Kodera, Rieko;Hirashima, Takeshi;Suzuki, Natsuko;Aoki, Ema;Hosoya, Mitsuru;Oshima, Taito;Hayashi, Toshiyuki;Koba, Shinji;Ohta, Motoko;Satoh, Noriyuki;Ito, Yasuki
目的：低密度脂蛋白（LDL）颗粒组成异常改变，如甘油三酯（TG）富集和大小减小，在糖尿病患者中很常见。一些队列研究表明，LDL-TG和sdldl -胆固醇(C)是除LDL-C外预测动脉粥样硬化性心血管疾病的敏感生物标志物。尽管sdLDL已被广泛研究，但对LDL-TG的特性知之甚少。我们研究了LDL-TG和sdLDL-C之间的异同。方法：采用糖尿病区域队列研究（ViNA队列）的1085例2型糖尿病患者的空腹血浆。LDL-TG和sdLDL-C浓度采用我们建立的均相法测定。在一部分受试者中，在餐后或使用降脂药物治疗后测量LDL-TG和sdLDL-C水平。结果：在四分位数分析中，较高的LDL-TG四分位数与女性和贝特类药物使用者的频率较高相关，而sdLDL-C四分位数与男性、饮酒和代谢综合征相关测量的频率相关。高四分位数的LDL-TG/LDL-C与吸烟、饮酒、贝特类药物使用者和他汀类药物使用者有关。LDL-TG与TG、LDL-C、sdLDL-C和载脂蛋白（apo） B显著相关，其中载脂蛋白ob是主要决定因素。LDL-TG与高敏c反应蛋白（CRP）相关，独立于其他脂质。平均LDL-TG不随禁食/非禁食而改变。他汀类药物降低了LDL-TG，而贝特类药物增加了它，但这些药物同样降低了sdLDL-C。结论：与血浆TG水平相比，LDL-TG水平受LDL颗粒数的调节更为紧密。SdLDL-C与代谢综合征相关因素密切相关，而LDL-TG与低度全身性炎症相关。
Aims: Abnormal compositional changes in low-density lipoprotein (LDL) particles, such as triglyceride (TG) enrichment and size reduction, are common in patients with diabetes. Several cohort studies have demonstrated that LDL-TG and sdLDL-cholesterol (C) are sensitive biomarkers for predicting atherosclerotic cardiovascular diseases beyond LDL-C. Although sdLDL has been extensively studied, little is known about the properties of LDL-TG. We investigated similarities or differences between LDL-TG and sdLDL-C. Methods: Fasting plasma was obtained from 1,085 patients with type 2 diabetes who were enrolled in the diabetes regional cohort study (ViNA Cohort). LDL-TG and sdLDL-C concentrations were measured using a homogeneous assay established by us. In a subset of subjects, LDL-TG and sdLDL-C levels were measured postprandially or after treatment with lipid-lowering drugs. Results: In a quartile analysis, higher LDL-TG quartiles were associated with higher frequency of female and fibrate users, whereas sdLDL-C quartiles were associated with frequency of men, drinking, and metabolic syndrome-related measurements. Higher quartiles of LDL-TG/LDL-C were associated with smoking, drinking, fibrate users, and statin users. LDL-TG was significantly correlated with TG, LDL-C, sdLDL-C, and apolipoprotein (apo) B, with apoB being the primary determinant. LDL-TG correlated to high sensitive C-reactive protein (CRP) independently of other lipids. Mean LDL-TG did not change with fasting/non-fasting. Statin treatment reduced LDL-TG, whereas fibrates increased it, but these drugs reduced sdLDL-C equally. Conclusions: LDL-TG levels were more tightly regulated by the number of LDL particles than plasma TG levels were. SdLDL-C was closely associated with metabolic syndrome-related factors, whereas LDL-TG was associated with low-grade systemic inflammation.
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影响因子：
5.3
作者：
Silbernagel, Guenther;Scharnagl, Hubert;Grammer, Tanja B.
通讯作者：
Grammer, Tanja B.
影响因子：
9.8
作者：
Hayashi, Toshiyuki;Hirano, Tsutornu;Adachi, Mitsuru
通讯作者：
Adachi, Mitsuru
影响因子：
8.2
作者：
LAAKSO, M;SARLUND, H;PYORALA, K
通讯作者：
PYORALA, K
影响因子：
37.8
作者：
März, W;Scharnagl, H;Winkelmann, BR
通讯作者：
Winkelmann, BR
影响因子：
4.4
作者：
Hirano T
通讯作者：
Hirano T