MicroRNAs in pancreatic malignancy: progress and promises.
MicroRNAs in pancreatic malignancy: progress and promises.
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DOI：
10.1016/j.canlet.2014.02.015
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发表时间：
2014-06-01
期刊：
影响因子：
9.7
通讯作者：
Singh, Ajay P.
中科院分区：
文献类型：
--
作者：
Srivastava, Sanjeev K.;Arora, Sumit;Singh, Seema;Bhardwaj, Arun;Averett, Courey;Singh, Ajay P.
尽管近年来取得了进展，但胰腺癌仍然是一个重大的临床挑战。其发病率和死亡率一直在持续上升，因此强调了对有效管理的新型诊断，预后和治疗工具的迫切需要。最近的研究表明，microRNAs（miRNAs/miRs）在包括胰腺癌在内的多种恶性肿瘤中表达失调，并在肿瘤的发生、发展和转移中发挥重要作用。此外，还确定了它们在癌症的治疗抗性中的重要参与。因此，全世界都对研究miRNA在胰腺癌发病机制中的作用以及利用其临床益处产生了极大的兴趣。在这篇综述中，我们总结了目前的知识在胰腺癌中的作用，并讨论了其作为诊断和预后生物标志物的潜在用途，并作为开发有效的治疗策略的新靶点。
Despite progress in recent years, pancreatic cancer still remains a major clinical challenge. Its incidence and mortality rates have been on consistent rise, thus underscoring the critical need for novel diagnostic, prognostic and therapeutic tools for its effective management. Recent studies have demonstrated that microRNAs (miRNAs/miRs) are deregulated in a variety of malignancies, including pancreatic cancer, and play a significant role in the initiation, progression and metastasis. Furthermore, their vital involvement in the therapeutic resistance of cancer has also been established. Hence, there has been enormous interest worldwide in investigating the roles of miRNAs in pancreatic cancer pathogenesis and exploiting their utility for clinical benefit. In this review, we summarize current knowledge on the role of miRNAs in pancreatic cancer and discuss their potential use as diagnostic and prognostic biomarkers, and as novel targets for development of effective therapeutic strategies.
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影响因子：
--
作者：
Hu, Yongjun;Ou, Yanglu;Sun, Weijia
通讯作者：
Sun, Weijia
影响因子：
3.6
作者：
Habbe, Nils;Koorstra, Jan-Bart M.;Maitra, Anirban
通讯作者：
Maitra, Anirban
影响因子：
3.7
作者：
Farhana L;Dawson MI;Murshed F;Das JK;Rishi AK;Fontana JA
通讯作者：
Fontana JA
影响因子：
3.2
作者：
Bhardwaj, Arun;Arora, Sumit;Singh, Ajay P.
通讯作者：
Singh, Ajay P.
DOI：
10.1158/1940-6207.capr-11-0299
发表时间：
2012-03
期刊：
Cancer prevention research (Philadelphia, Pa.)
影响因子：
--
作者：
Bao B;Wang Z;Ali S;Ahmad A;Azmi AS;Sarkar SH;Banerjee S;Kong D;Li Y;Thakur S;Sarkar FH
通讯作者：
Sarkar FH