Molecular epidemiology of tuberculosis in Kaohsiung City located at southern Taiwan, 2000-2008.
Molecular epidemiology of tuberculosis in Kaohsiung City located at southern Taiwan, 2000-2008.
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DOI：
10.1371/journal.pone.0117061
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Dou HY
中科院分区：
文献类型：
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作者：
Chen YY;Chang JR;Kuo SC;Tseng FC;Huang WC;Huang TS;Chen YS;Chiueh TS;Sun JR;Su IJ;Dou HY
我们提出第一个综合分析结核分枝杆菌（MTB）分离流行在台湾南部。本研究对高雄地区421株结核分枝杆菌进行基因型分析。对421株结核分枝杆菌进行spoligotyping和MIRU-VNTR分型分析。同时分析耐药模式。2000-2008年，台湾南部EAI（东非-印度）菌株的比例有所增加，而北京谱系的比例保持不变。与北京基因型相比，EAI基因型感染的聚类频率更高（优势比= 3.6,p<0.0001）。值得注意的是，结核分枝杆菌对链霉素（STR）的耐药性随着时间的推移显著增加，但对其他抗生素（包括多药耐药性）的耐药性却没有增加。对与STR抗性相关的三个主要基因（gidB、rpsL和rrs）进行了测序，并确定了特异性突变。本研究结果显示，台湾高雄地区EAI菌株具有高度传染性，且2000 ~ 2008年对STR的抗性有所增加。
We present the first comprehensive analysis of Mycobacterium tuberculosis (MTB) isolates circulating in southern Taiwan. In this 9-year population-based study, the TB situation in the Kaohsiung region was characterized by genotypic analysis of 421 MTB isolates. All 421 isolates of MTB were analyzed by spoligotyping and MIRU-VNTR typing. Drug-resistance patterns were also analyzed. The percentage of EAI (East African-Indian) strains increased across sampling years (2000–2008) in southern Taiwan, whereas the proportion of Beijing lineages remained unchanged. Clustering was more frequent with EAI genotype infections (odds ratio = 3.6, p<0.0001) when compared to Beijing genotypes. Notably, MTB resistance to streptomycin (STR) had significantly increased over time, but resistance to other antibiotics, including multidrug resistance, had not. Three major genes (gidB, rpsL and rrs) implicated in STR resistance were sequenced and specific mutations identified. This study revealed that EAI strains were highly transmissible and that STR resistance has increased between 2000 and 2008 in Kaohsiung, Taiwan.
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影响因子：
3.7
作者：
Dou HY;Tseng FC;Lin CW;Chang JR;Sun JR;Tsai WS;Lee SY;Su IJ;Lu JJ
通讯作者：
Lu JJ
影响因子：
6.7
作者：
Pepperell CS;Casto AM;Kitchen A;Granka JM;Cornejo OE;Holmes EC;Birren B;Galagan J;Feldman MW
通讯作者：
Feldman MW
影响因子：
9.4
作者：
Spies, Fernanda S.;Ribeiro, Andrezza W.;Zaha, Arnaldo
通讯作者：
Zaha, Arnaldo
影响因子：
3.2
作者：
Huang, Shiang-Fen;Su, Wei-Juin;Yu, Ming-Chih
通讯作者：
Yu, Ming-Chih
影响因子：
16.6
作者：
通讯作者：
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