Effects of lorazepam on cardiac vagal tone during rest and mental stress: assessment by means of spectral analysis
Effects of lorazepam on cardiac vagal tone during rest and mental stress: assessment by means of spectral analysis
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劳拉西泮对休息和精神应激期间心脏迷走神经张力的影响：通过频谱分析进行评估
DOI：
10.1007/bf02245447
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发表时间：
1994
影响因子：
3.4
通讯作者：
P. Moleman
中科院分区：
文献类型：
--
作者：
J. Tulen;G. Mulder;L. Pepplinkhuizen;A. Man In't Veld;H. G. Steenis;P. Moleman
静脉注射劳拉西泮对血液动力学波动的剂量依赖性影响进行了研究，通过频谱分析，以阐明交感神经和副交感神经成分在心血管控制的情况下，休息和精神压力后苯二氮卓类药物管理。在一项双盲随机交叉研究中，9名男性志愿者参加了两个阶段：安慰剂和劳拉西泮阶段。在这些会议期间，受试者重复进行10分钟版本的Stroop颜色词测试（CWT），CWT之间休息10分钟。在每个休息期之前，以0.0、0.06、0.13、0.25和0.5 mg的递增剂量给予劳拉西泮（总累积剂量：0.94 mg）。在安慰剂治疗期间，受试者接受了5次安慰剂注射。对于9名受试者中的5名，劳拉西泮治疗是他们的第一次治疗。连续记录心率（HR）、血压（BP）和呼吸。每2.5分钟计算HR、收缩压（SBP）和舒张压（DBP）的功率谱。针对三个频带评估频谱密度：低（LFB：0.02-0.06 Hz）、中（MFB：0.07-0.14 Hz）和高（HFB：0.15-0.40 Hz）。在连续休息期间，劳拉西泮可使HR呈剂量依赖性下降，HR的LFB、MFB和HFB功率呈剂量依赖性增加，但劳拉西泮对BP无影响。0.44 mg劳拉西泮对HR和HFB功率的影响以及0.94 mg劳拉西泮对LFB和MFB中HR波动的影响均显著。劳拉西泮不影响CWT的心血管反应。我们的数据强调，苯二氮卓类药物可以对副交感神经活动产生特定的影响：劳拉西泮诱导心脏迷走神经张力的剂量依赖性增加，导致HR降低和HR变异性增加，但仅在休息期间。低剂量劳拉西泮后观察到的迷走神经张力增加与交感神经活动减少、呼吸改变或镇静作用增加无关。
Dose-dependent effects of intravenously administered lorazepam on haemodynamic fluctuations were studied by means of spectral analysis, in order to elucidate sympathetic and parasympathetic components in cardiovascular control during situations of rest and mental stress after benzodiazepine administration. In a double-blind randomized cross-over study, nine male volunteers participated in two sessions: a placebo and lorazepam session. During these sessions, the subjects repeatedly performed a 10-min version of the Stroop Color Word Test (CWT), with 10 min of rest between the CWTs. Lorazepam was administered before each rest period in increasing doses of 0.0, 0.06, 0.13, 0.25 and 0.5 mg (total cumulative dose: 0.94 mg). During the placebo session the subjects received five placebo injections. For five of the nine subjects the lorazepam session was their first session. Heat rate (HR), blood pressure (BP) and respiration were recorded continuously. Power spectra were calculated per 2.5-min periods for HR, systolic (SBP) and diastolic BP (DBP). Spectral density was assessed for three frequency bands: low (LFB: 0.02–0.06 Hz), mid (MFB: 0.07–0.14 Hz) and high (HFB: 0.15–0.40 Hz). During the consecutive periods of rest, lorazepam induced a dose-dependent decrease in HR, and a dose-dependent increase in LFB, MFB and HFB power of HR, but lorazepam had no effect on BP. The effects were significant after 0.44 mg lorazepam for HR and HFB power, and after 0.94 mg lorazepam for the HR fluctuations in the LFB and MFB. Lorazepam did not influence the cardiovascular responses to the CWT. Our data underline that benzodiazepines can exert a specific influence on parasympathetic activity: lorazepam induced dose-dependent increases in cardiac vagal tone, resulting in decreased HR and increased HR variability, but only during periods of rest. The increase in vagal tone observed after low doses of lorazepam was not related to diminished sympathetic activity, altered respiration, or increased sedation.
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影响因子：
--
作者：
POMERANZ, B;MACAULAY, RJB;BENSON, H
通讯作者：
BENSON, H
苯二氮卓类药物会减弱蓝斑的单个单位活性。
影响因子：
6.1
作者：
Grant,SJ;Huang,YH;RedmondJr,DE
通讯作者：
RedmondJr,DE
影响因子：
56.9
作者：
AKSELROD, S;GORDON, D;COHEN, RJ
通讯作者：
COHEN, RJ
影响心脏迷走神经控制的药理操作对大鼠心率、心率变异性和呼吸的影响。
影响因子：
3.7
作者：
Yongue,BG;McCabe,PM;Porges,SW;Rivera,M;Kelley,SL;Ackles,PK
通讯作者：
Ackles,PK
影响因子：
--
作者：
SAUL, JP;BERGER, RD;COHEN, RJ
通讯作者：
COHEN, RJ