Hypoconnectivity between anterior insula and amygdala associates with future vulnerabilities in social development in a neurodiverse sample of neonates.
Hypoconnectivity between anterior insula and amygdala associates with future vulnerabilities in social development in a neurodiverse sample of neonates.
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DOI：
10.1038/s41598-022-20617-6
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发表时间：
2022-09-28
影响因子：
4.6
通讯作者：
Chawarska, Katarzyna
中科院分区：
文献类型：
--
作者：
Scheinost, Dustin;Chang, Joseph;Lacadie, Cheryl;Brennan-Wydra, Emma;Foster, Rachel;Boxberger, Alexandra;Macari, Suzanne;Vernetti, Angelina;Constable, R. Todd;Ment, Laura R.;Chawarska, Katarzyna
在自闭症中，涉及前岛叶（aINS）（突显网络中的关键节点）的静息状态功能连接（FC）发生了改变。在这里，我们首次检查了足月、经后年龄 (PMA) 匹配的新生儿样本（平均 44.0 周，SD = 1.5）中 aINS 和全脑之间的 FC，这些新生儿由于家族史而极有可能 (HL) 患自闭症 (n = 12) 和没有自闭症家族史的对照 (n = 41)（低可能性， LL）。使用第一年清单 (FYI) 在参与者的子样本 (25/53) 中评估 12 至 18 个月期间的与自闭症相关的行为（M = 17.3 个月，SD = 2.5）。与 LL 对照相比，HL 新生儿表现出左 aINS 和左杏仁核之间的连接性低下。两个节点之间较低的连通性与社会领域较高的 FYI 风险评分相关（r(25) = −0.561，p = .003），并且当考虑到孕产妇心理健康因素时，这种关联仍然很强。考虑到 LL 参与者的子样本 (n = 14/41) 在 PMA 31 和 34 周的胎儿期接受了脑成像，在一项探索性分析中，我们前瞻性地评估了 LaINS-Lamy 连接的发展，发现这两个区域在整个妊娠晚期强烈地共同激活。该研究将左前岛叶-杏仁核连接确定为进一步研究神经回路的潜在目标，该神经回路增加了新生儿和潜在产前期间未来出现与自闭症相关的社会行为的可能性。
Altered resting state functional connectivity (FC) involving the anterior insula (aINS), a key node in the salience network, has been reported consistently in autism. Here we examined, for the first time, FC between the aINS and the whole brain in a sample of full-term, postmenstrual age (PMA) matched neonates (mean 44.0 weeks, SD = 1.5) who due to family history have high likelihood (HL) for developing autism (n = 12) and in controls (n = 41) without family history of autism (low likelihood, LL). Behaviors associated with autism were evaluated between 12 and 18 months (M = 17.3 months, SD = 2.5) in a subsample (25/53) of participants using the First Year Inventory (FYI). Compared to LL controls, HL neonates showed hypoconnectivity between left aINS and left amygdala. Lower connectivity between the two nodes was associated with higher FYI risk scores in the social domain (r(25) = −0.561, p = .003) and this association remained robust when maternal mental health factors were considered. Considering that a subsample of LL participants (n = 14/41) underwent brain imaging during the fetal period at PMA 31 and 34 weeks, in an exploratory analysis, we evaluated prospectively development of the LaINS-Lamy connectivity and found that the two areas strongly coactivate throughout the third trimester of pregnancy. The study identifies left lateralized anterior insula—amygdala connectivity as a potential target of further investigation into neural circuitry that enhances likelihood of future onset of social behaviors associated with autism during neonatal and potentially prenatal periods.
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影响因子：
3
作者：
Joshi A;Scheinost D;Okuda H;Belhachemi D;Murphy I;Staib LH;Papademetris X
通讯作者：
Papademetris X
DOI：
10.1016/j.jaac.2018.06.015
发表时间：
2018-10
影响因子：
13.3
作者：
Fishman I;Linke AC;Hau J;Carper RA;Müller RA
通讯作者：
Müller RA
影响因子：
4.6
作者：
Gholipour A;Rollins CK;Velasco-Annis C;Ouaalam A;Akhondi-Asl A;Afacan O;Ortinau CM;Clancy S;Limperopoulos C;Yang E;Estroff JA;Warfield SK
通讯作者：
Warfield SK
影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
MERMELSTEIN, R
影响因子：
3.9
作者：
Macari SL;Wu GC;Powell KK;Fontenelle S 4th;Macris DM;Chawarska K
通讯作者：
Chawarska K