A Review of Keratin-Based Biomaterials for Biomedical Applications

A Review of Keratin-Based Biomaterials for Biomedical Applications
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DOI:
10.3390/ma3020999
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发表时间:
2010-02-03
期刊:
影响因子:
3.4
通讯作者:
Van Dyke ME
Van Dyke ME
中科院分区:
材料科学3区
文献类型:
--
作者:
Rouse JG;Van Dyke ME

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在过去的一个世纪里,从头发和羊毛纤维中提取、纯化和表征角蛋白的进展导致了基于角蛋白的生物材料平台的发展。像许多天然衍生的生物分子一样,角蛋白具有内在的生物活性和生物相容性。此外,提取的角蛋白能够形成调节细胞识别和行为的自组装结构。这些特性导致了角蛋白生物材料在伤口愈合、药物输送、组织工程、创伤和医疗设备方面的应用。本文综述了角蛋白研究的历史和角蛋白生物材料在生物医学领域的应用进展。
Advances in the extraction, purification, and characterization of keratin proteins from hair and wool fibers over the past century have led to the development of a keratin-based biomaterials platform. Like many naturally-derived biomolecules, keratins have intrinsic biological activity and biocompatibility. In addition, extracted keratins are capable of forming self-assembled structures that regulate cellular recognition and behavior. These qualities have led to the development of keratin biomaterials with applications in wound healing, drug delivery, tissue engineering, trauma and medical devices. This review discusses the history of keratin research and the advancement of keratin biomaterials for biomedical applications.
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