Evaluation of transcatheter heart valve biomaterials: Biomechanical characterization of bovine and porcine pericardium.
Evaluation of transcatheter heart valve biomaterials: Biomechanical characterization of bovine and porcine pericardium.
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DOI：
10.1016/j.jmbbm.2017.08.013
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发表时间：
2017-11
影响因子：
3.9
通讯作者：
Sun W
中科院分区：
文献类型：
--
作者：
Caballero A;Sulejmani F;Martin C;Pham T;Sun W
牛心包(BP)已被认为是开发外科生物瓣膜(BHV)和经导管主动脉瓣(TAV)的理想生物材料。猪心包(PP)和年轻的BP由于厚度较小，已被建议作为TAV小叶生物材料的候选材料；然而，它们的力学和结构特性仍有待充分表征。本研究对化学处理的厚(PPK)和薄(PPN)PP以及胎儿(FBP)、小牛(CBP)和成人(ABP)BP组织的材料性能进行了表征，以更好地了解它们的力学行为。采用平面双轴试验和单轴破坏试验方法来量化组织的力学响应和破坏特性。通过组织学分析检测纤维特性。ABP和CBP组织明显比年轻的FBP组织僵硬和坚固。组织学分析显示，未成熟胶原纤维在FBP组织中的浓度明显高于ABP和CBP组织。虽然PP组织最薄，但它们比BP组织更僵硬，伸展性更差。由于CBP组织的力学性能与ABP组织相当，但厚度明显减少，因此CBP组织可能比ABP组织更适合制作TAV。尽管FBP组织的厚度减少，柔韧性更高，但它更弱，应该进行更详细的研究。虽然PP组织是最薄的，但它们的延伸性最小，并且比BP组织在更早的应变时失效。PP和BP组织之间的差异值得进一步研究，并建议在TAV的制造中不应互换使用。
Bovine pericardium (BP) has been identified as a choice biomaterial for the development of surgical bioprosthetic heart valves (BHV) and transcatheter aortic valves (TAV). Porcine pericardium (PP) and younger BP have been suggested as candidates TAV leaflet biomaterials for smaller-profile devices due to their reduced thickness; however, their mechanical and structural properties remain to be fully characterized. This study characterized the material properties of chemically treated thick (PPK) and thin (PPN) PP, as well as fetal (FBP), calf (CBP) and adult (ABP) BP tissues in order to better understand their mechanical behavior. Planar biaxial testing and uniaxial failure testing methods were employed to quantify tissue mechanical responses and failure properties. Fiber characteristics were examined using histological analysis. ABP and CBP tissues were significantly stiffer and stronger than the younger FBP tissues. Histological analysis revealed a significantly larger concentration of thin immature collagen fibers in the FBP tissues than in the ABP and CBP tissues. While PP tissues were thinnest, they were stiffer and less extensible than the BP tissues. Due to comparable mechanical properties but significantly reduced thickness, CBP tissue may be a more suitable material for TAV manufacturing than ABP tissue. FBP tissue, despite its reduced thickness and higher flexibility, was weaker and should be studied in more detail. Although PP tissues are the thinnest, they were least extensible and failed at earlier strain than BP tissues. The differences between PP and BP tissues should be further investigated and suggest that they should not be used interchangeably in the manufacturing of TAV.
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影响因子：
37.8
作者：
Aikawa, E;Whittaker, P;Schoen, FJ
通讯作者：
Schoen, FJ
影响因子：
3.8
作者：
LaCroix, Andrew S.;Duenwald-Kuehl, Sarah E.;Brickson, Stacey;Akins, Tiffany L.;Diffee, Gary;Aiken, Judd;Vanderby, Ray, Jr.;Lakes, Roderic S.
通讯作者：
Lakes, Roderic S.
影响因子：
168.9
作者：
Kapadia, Samir R.;Leon, Martin B.;Smith, Craig R.
通讯作者：
Smith, Craig R.
DOI：
10.1002/jbm.820220202
发表时间：
1988-02-01
期刊：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
影响因子：
--
作者：
CROFTS, CE;TROWBRIDGE, EA
通讯作者：
TROWBRIDGE, EA
影响因子：
1.5
作者：
CURWIN, SL;ROY, RR;VAILAS, AC
通讯作者：
VAILAS, AC