Effect of age and exercise on the viscoelastic properties of rat tail tendon.
Effect of age and exercise on the viscoelastic properties of rat tail tendon.
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DOI：
10.1007/s10439-013-0796-4
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发表时间：
2013-06
影响因子：
3.8
通讯作者：
Lakes, Roderic S.
中科院分区：
文献类型：
--
作者：
LaCroix, Andrew S.;Duenwald-Kuehl, Sarah E.;Brickson, Stacey;Akins, Tiffany L.;Diffee, Gary;Aiken, Judd;Vanderby, Ray, Jr.;Lakes, Roderic S.
肌腱的机械性能被认为在老化过程中会降低，但随着运动而改善。剩下的问题是，老年动物的运动是否提供了足够的再生，系统的刺激，以恢复年轻的机械行为。在这里，我们解决了这个问题，从老年和运动大鼠的尾肌腱，这将受到全身效应，但不直接从运动方案的负荷。24个月大的大鼠进行三种跑步机运动训练方案之一，持续12个月：久坐（以0°倾斜行走5分钟/天）、中度（以0°倾斜跑步30分钟/天）或高度（以4°倾斜跑步30分钟/天）。一组9月龄大鼠用于提供成年对照，而一组3月龄大鼠用于提供幼年对照。在处死时收获肌腱并进行机械测试。结果表明，模量，极限应力，松弛速率和松弛百分比显着的年龄依赖性差异。松弛速率是应变依赖性的，符合非线性叠加或Schapery模型，但不与准线性粘弹性（QLV）。运动数据的趋势表明，随着运动，肌腱呈现年轻大鼠的弹性特征（较低的弹性模量和极限应力）。
Tendon mechanical properties are thought to degrade during aging but improve with exercise. A remaining question is whether exercise in aged animals provides sufficient regenerative, systemic stimulus to restore younger mechanical behaviors. Herein we address that question with tail tendons from aged and exercised rats, which would be subject to systemic effects but not direct loading from the exercise regimen. Twenty-four month old rats underwent one of three treadmill exercise training protocols for 12 months: sedentary (walking at 0° incline for 5 min/day), moderate (running at 0° incline for 30 min/day), or high (running at 4° incline for 30 min/day). A group of 9 month old rats were used to provide an adult control, while a group of 3 month old rats provided a young control. Tendons were harvested at sacrifice and mechanically tested. Results show significant age-dependent differences in modulus, ultimate stress, relaxation rate, and percent relaxation. Relaxation rate was strain-dependent, consistent with nonlinear superposition or Schapery models but not with quasilinear viscoelasticity (QLV). Trends in exercise data suggest that with exercise, tendons assume the elastic character of younger rats (lower elastic modulus and ultimate stress).
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DOI：
10.1093/gerona/gls146
发表时间：
2012-11-01
影响因子：
5.1
作者：
Chung, Eunhee;Diffee, Gary M.
通讯作者：
Diffee, Gary M.
影响因子：
2.4
作者：
CHIMICH, D;SHRIVE, N;BRAY, R
通讯作者：
BRAY, R
影响因子：
3.8
作者：
Elliott, DM;Robinson, PS;Soslowsky, LJ
通讯作者：
Soslowsky, LJ
影响因子：
4.8
作者：
FLAHIFF, CM;BROOKS, AT;NICHOLAS, RW
通讯作者：
NICHOLAS, RW
DOI：
10.1115/1.2898732
发表时间：
2008-04-01
影响因子：
1.7
作者：
Goh, K. L.;Holmes, D. F.;Wess, T. J.
通讯作者：
Wess, T. J.