COPD: To Be or Not to Be, That is the Question.
COPD: To Be or Not to Be, That is the Question.
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DOI：
10.1016/j.amjmed.2019.04.047
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发表时间：
2019-11
期刊：
影响因子：
--
通讯作者：
Guerra S
中科院分区：
文献类型：
--
作者：
Polverino F;Sam A;Guerra S
随着我们对慢性阻塞性肺病 (COPD) 自然史的了解不断深入，仅仅基于成人生活中吸烟引起的肺功能加速衰退的概念模型已经不足以描述这种疾病的复杂性，人们越来越关注生命早期发生的事件或发育过程改变可能产生的影响。此外，不同表型的慢性阻塞性肺病的病理生物学机制之间出现了显着的异质性，这表明有效的疾病管理将需要很大程度上基于潜在的生物学机制（内型）的个体化治疗方法。在这篇综述中，我们将从流行病学、病理学和临床的角度讨论慢性阻塞性肺病的许多方面，并认为气流受限包含多种表现形式，这些表现形式过于多样化，无法集中在同一诊断标签下。
As our knowledge on the natural history of chronic obstructive pulmonary disease (COPD) progresses, a conceptual model simply based on an accelerated decline of lung function in adult life in response to smoking has become inadequate to capture the complexity of this disease, and increasing attention is being given to possible contributions from events or alterations of developmental processes that take place earlier in life. In addition, a remarkable heterogeneity has emerged among the pathobiological mechanisms that are involved in different phenotypes of COPD, suggesting that an effective disease management will require individualized treatment approaches largely based on the underlying biological mechanisms (endotypes). In this review, we will discuss the many faces of COPD from an epidemiological, pathobiological, and clinical standpoint and argue that airflow limitation encompasses a number of manifestations that are too diverse to be still clustered under the same diagnostic label.
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DOI：
10.1164/rccm.200811-1757st
发表时间：
2010-09-01
影响因子：
24.7
作者：
Eisner, Mark D.;Anthonisen, Nicholas;Balmes, John R.
通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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