Respiration pattern variability and related default mode network connectivity are altered in remitted depression
Respiration pattern variability and related default mode network connectivity are altered in remitted depression
复制标题
缓解抑郁症时呼吸模式变异性和相关默认模式网络连接发生改变
DOI：
10.1017/s0033291717003890
复制
发表时间：
2018
影响因子：
6.9
通讯作者：
Kirsch P
中科院分区：
文献类型：
--
作者：
Zamoscik VE;Schmidt SNL;Gerchen MF;Samsouris C;Timm C;Kuehner C;Kirsch P
背景对健康参与者和呼吸系统疾病患者的研究表明呼吸和情绪之间存在关系。本分析的目的是调查情绪挑战缓解抑郁参与者是否表现出更高的呼吸模式变异性（RPV），以及这是否与情绪、临床结果和增加的默认模式网络连接有关。n = 30]和匹配的健康对照（HC，n = 30）。通过内置呼吸带测量呼吸。此外，还进行了问卷调查、日常生活情绪评估和3年随访。对于复制，我们分析了RPV在一个独立的样本53 rMDD谁经历了相同的fMRI paradigm.ResultsDuring悲伤的情绪，rMDD与HC相比，表现出更大的RPV，具有较高的变异性，暂停时间和呼吸频率和较低的呼气吸气比。较高的RPV与较低的日常生活情绪有关，并预测较高的抑郁评分以及3年随访期间的复发率。此外，在rMDD与HC相比，更高的主呼吸频率表现出更积极的关联与连接的后扣带皮层和右侧海马旁gyrus.ConclusionsThe结果表明RPV，情绪和抑郁症之间的关系的行为和神经水平。根据我们的研究结果，我们提出了干预措施，重点是呼吸是一个有前途的额外工具，在治疗抑郁症。
BackgroundStudies with healthy participants and patients with respiratory diseases suggest a relation between respiration and mood. The aim of the present analyses was to investigate whether emotionally challenged remitted depressed participants show higher respiration pattern variability (RPV) and whether this is related to mood, clinical outcome and increased default mode network connectivity.MethodsTo challenge participants, sad mood was induced with keywords of personal negative life events in individuals with remitted depression [recurrent major depressive disorder (rMDD), n = 30] and matched healthy controls (HCs, n = 30) during functional magnetic resonance imaging. Respiration was measured by means of a built-in respiration belt. Additionally, questionnaires, a daily life assessment of mood and a 3 years follow-up were applied. For replication, we analysed RPV in an independent sample of 53 rMDD who underwent the same fMRI paradigm.ResultsDuring sad mood, rMDD compared with HC showed greater RPV, with higher variability in pause duration and respiration frequency and lower expiration to inspiration ratio. Higher RPV was related to lower daily life mood and predicted higher depression scores as well as relapses during a 3-year follow-up period. Furthermore, in rMDD compared with HC higher main respiration frequency exhibited a more positive association with connectivity of the posterior cingulate cortex and the right parahippocampal gyrus.ConclusionsThe results suggest a relation between RPV, mood and depression on the behavioural and neural level. Based on our findings, we propose interventions focusing on respiration to be a promising additional tool in the treatment of depression.
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影响因子：
25.8
作者：
Kaiser, Roselinde H.;Andrews-Hanna, Jessica R.;Wager, Tor D.;Pizzagalli, Diego A.
通讯作者：
Pizzagalli, Diego A.
影响因子：
7.3
作者：
Yamada S;Miyazaki M;Yamashita Y;Ouyang C;Yui M;Nakahashi M;Shimizu S;Aoki I;Morohoshi Y;McComb JG
通讯作者：
McComb JG
不要担心，要注意：诱发的忧虑和正念对非焦虑人群呼吸变异的影响。
影响因子：
3
作者：
E. Vlemincx;D. Vigo;Debora Vansteenwegen;O. Van den Bergh;I. Van Diest
通讯作者：
I. Van Diest
哮喘合并COPD患者的心理状态评估。
DOI：
--
发表时间：
2012
期刊：
Iranian Journal of Allergy, Asthma and Immunology
影响因子：
--
作者：
A. Asnaashari;A. Talaei;Baghban Haghigh
通讯作者：
Baghban Haghigh
影响因子：
4.2
作者：
Zamoscik, Vera;Huffziger, Silke;Kirsch, Peter
通讯作者：
Kirsch, Peter