The composition of the gut microbiome differs among community dwelling older people with good and poor appetite.
The composition of the gut microbiome differs among community dwelling older people with good and poor appetite.
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DOI：
10.1002/jcsm.12683
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发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
Steves CJ
中科院分区：
文献类型：
--
作者：
Cox NJ;Bowyer RCE;Ni Lochlainn M;Wells PM;Roberts HC;Steves CJ
老年性厌食症在老年人肌肉减少症的发展中是常见的和重要的。已经提出了肠道微生物群和肌肉减少症之间的联系。肠道功能紊乱也被认为是衰老性厌食症的一部分，但这与肠道微生物群的关系尚不清楚。了解这种关系可能会提供一个新的干预措施的基础上，厌食症的老化和肌肉减少症。这项研究探讨了社区居住的健康老年人之间肠道微生物群的组成差异，食欲良好或食欲不振，以及肌肉减少症的相关差异。我们通过简化营养食欲问卷（SNAQ）评估年龄≥65岁的TwinsUK队列成员的食欲。使用776名个体的样本池，根据16 S rRNA测序数据估计现有的微生物组数据，我们确定了102例病例（SNAQ评分< 14）（95%女性，平均年龄68岁）与对照组匹配（SNAQ > 14）对体重指数，性别，年龄，饮食，卡路里消耗，虚弱，抗生素使用，社会经济地位，和技术变量来最小化混淆的微生物群关联。物种的丰度和多样性，成分差异，配对的类群丰度的差异进行了比较的情况下和控制。此外，我们比较了病例组和对照组的肌肉减少症，通过肌肉质量（非典型瘦体重/身高2）和力量（椅子站立时间，单位为秒）进行测量。食欲不振的病例减少了肠道微生物组的物种丰富度和多样性（调整后的观察值：beta =-0.2，P < 0.001;调整后的香农：β =-0.17，P = 0.0135），显著成分差异（经调整的非参数多变量方差分析，P = 0.0095），分类群丰度差异显著，包括毛螺菌属减少（logFC =-1.015，q = 0.023）。在全女性亚组分析中，食欲不佳的病例显示肌肉力量下降（11.03 s vs. 9.26 s，P = 0.02）。这项研究是第一次观察到健康社区居住的老年人之间肠道微生物群组成的差异，食欲良好和食欲不佳。我们发现，与正常力量的人相比，肌肉力量减少的女性个体食欲不佳。这些关联需要进一步研究，以了解因果关系和相互作用机制，为针对肠道微生物群的潜在策略提供信息，作为衰老厌食症和肌肉减少症的新干预措施。
Anorexia of ageing is common and important in the development of sarcopenia in older individuals. Links have been proposed between the gut microbiota and sarcopenia. Disordered gut function is also recognized in anorexia of ageing, but how this may relate to resident gut microbiota is unexplored. Understanding this relationship may provide a basis for novel interventions for anorexia of ageing and sarcopenia. This study explores compositional differences of the gut microbiota between community dwelling healthy older adults with good or poor appetite, and associated differences in sarcopenia. We assessed appetite by the Simplified Nutritional Appetite Questionnaire (SNAQ) in members of the TwinsUK cohort aged ≥65 years. Using a pool of 776 individuals with existing microbiome data estimated from 16S rRNA sequencing data, we identified 102 cases (SNAQ score < 14) (95% female, mean age 68 years) matched to controls (SNAQ > 14) on body mass index, gender, age, diet, calorie consumption, frailty, antibiotic use, socio‐economic status, and technical variables to minimize confounding microbiota associations. Species abundance and diversity, compositional differences, and paired differences in taxa abundance were compared between cases and controls. Additionally, we compared case and controls for sarcopenia as measured by muscle mass (appendicular lean mass/height2) and strength (chair stand time in seconds). Cases with poor appetite had reduced species richness and diversity of their gut microbiome (adjusted OBSERVED: beta = −0.2, P < 0.001; adjusted SHANNON: beta = −0.17, P = 0.0135), significant compositional differences (adjusted non‐parametric multivariate analysis of variance, P = 0.0095), and significant differences in taxa abundance including reduction of genus Lachnospira (logFC = −1.015, q = 0.023). In all‐female subgroup analysis, cases with poor appetite demonstrated reduction in muscle strength (11.03 s vs. 9.26 s, P = 0.02). This study is the first to observe differences in the composition of gut microbiota between healthy community dwelling older individuals with good and poor appetite. We found female individuals with reduced muscle strength had poor appetite compared with those with normal strength. These associations require further examination to understand causality and mechanisms of interaction, to inform potential strategies targeting the gut microbiota as a novel intervention for anorexia of ageing and sarcopenia.
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影响因子：
48
作者：
Callahan BJ;McMurdie PJ;Rosen MJ;Han AW;Johnson AJ;Holmes SP
通讯作者：
Holmes SP
影响因子：
5.4
作者：
Huang, Yi-Chen;Wahlqvist, Mark L.;Lee, Meei-Shyuan
通讯作者：
Lee, Meei-Shyuan
影响因子：
2.4
作者：
Marounek, M;Dusková, D
通讯作者：
Dusková, D
DOI：
10.1007/s12603-020-1344-1
发表时间：
2020
期刊：
The journal of nutrition, health & aging
影响因子：
--
作者：
Barger K;Langsetmo L;Orwoll ES;Lustgarten MS
通讯作者：
Lustgarten MS
影响因子：
5.9
作者：
Jeffery IB;O'Toole PW
通讯作者：
O'Toole PW