Physical Activity and Glycemic Control Status in Chinese Patients with Type 2 Diabetes: A Secondary Analysis of a Randomized Controlled Trial.
Physical Activity and Glycemic Control Status in Chinese Patients with Type 2 Diabetes: A Secondary Analysis of a Randomized Controlled Trial.
复制标题
中国 2 型糖尿病患者的体力活动和血糖控制状况：随机对照试验的二次分析
DOI：
10.3390/ijerph18084292
复制
发表时间：
2021-04-18
影响因子：
--
通讯作者：
Xu WH
中科院分区：
文献类型：
--
作者：
Yao WY;Han MG;De Vito G;Fang H;Xia Q;Chen Y;Liu X;Wei Y;Rothman RL;Xu WH
该次要分析旨在评价中国2型糖尿病（T2DM）患者中体力活动（PA）对血红蛋白A1c（HbA1c）水平的独立影响。来自中国上海市8个社区的799例T2DM患者被随机分为一个对照组和三个干预组，接受为期1年的健康素养、运动或两者兼而有之的干预。在基线、12个月和24个月时使用国际体力活动问卷测量PA，并量化为代谢当量（Mets）。采用多水平混合回归模型分析PA与HbA1c水平的关系。在调整潜在混杂因素（包括PA水平与初始PA或HbA1c的相互作用）后，在12个月时，观察到总体PA的中三分位组与最低三分位组患者的HbA1c显著改善（β：−3.47，95%CI：−5.33，−1.60）以及24个月时最高与最低三分位组的受试者（β：−0.50，95%CI：−1.00，−0.01），导致整个两年随访期间的β（95%CI）为−3.49（95%CI：−5.87，−1.11）。当使用世界卫生组织（WHO）的建议作为分界点，根据受试者的运动水平对受试者进行分类时，也观察到了负相关。仅在基线HbA1c或PA水平较低或两者均较低的患者中观察到较高PA水平的有益作用（所有相互作用p值<0.05）。我们的研究结果为PA的有益作用提供了证据，并建议运动干预应针对身体不活跃的患者，以提高其PA水平到生理阈值。
This secondary analysis was designed to evaluate the independent effect of physical activity (PA) on hemoglobin A1c (HbA1c) level in Chinese patients with type 2 diabetes mellitus (T2DM). A total of 799 T2DM patients from eight communities of Shanghai, China, were randomized into one control arm and three intervention arms receiving 1-year interventions of health literacy, exercise, or both. PA was measured using the International Physical Activity Questionnaire at baseline, 12 months, and 24 months and quantified as metabolic equivalents (Mets). A multiple level mixed regression model was applied to evaluate the associations between PA and HbA1c level. After adjusting for potential confounders including interaction of PA level with initial PA or HbA1c, a significant improved HbA1c was observed for the patients in the medium versus the lowest tertile groups of overall PA at 12 months (β: −3.47, 95%CI: −5.33, −1.60) and for those in the highest versus the lowest tertile group at 24 months (β: −0.50, 95%CI: −1.00, −0.01), resulting in a β (95%CI) of −3.49 (95%CI: −5.87, −1.11) during the whole two-year period of follow-up. The negative association was also observed when the subjects were classified according to their exercise levels using the World Health Organization (WHO) recommendation as a cut-off point. The beneficial effect of higher PA level was only observed among patients having a lower level of baseline HbA1c or PA or both (all p values for interaction <0.05). Our results provide evidence for the beneficial effect of PA and suggest that the exercise intervention should be addressed to the physically inactive patients to improve their PA level to a physiological threshold.
登录
查看更多内容
影响因子：
9.1
作者：
Dutton GR;Lewis CE
通讯作者：
Lewis CE
影响因子：
4.7
作者：
Liu, Hongliang;Liu, Zhensheng;Wei, Qingyi
通讯作者：
Wei, Qingyi
影响因子：
2.5
作者：
Miquelon, Paule;Castonguay, Alexandre
通讯作者：
Castonguay, Alexandre
DOI：
10.1016/s0197-2456(00)00081-7
发表时间：
2000-10-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
Chao, D;Foy, CG;Farmer, D
通讯作者：
Farmer, D
影响因子：
5.8
作者：
Blomster, J. I.;Chow, C. K.;Hillis, G. S.
通讯作者：
Hillis, G. S.