Life event stress and chronic obstructive pulmonary disease (COPD): associations with mental well-being and quality of life in a population-based study.
Life event stress and chronic obstructive pulmonary disease (COPD): associations with mental well-being and quality of life in a population-based study.
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DOI：
10.1136/bmjopen-2012-001674
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发表时间：
2012
期刊：
影响因子：
2.9
通讯作者：
Ng TP
中科院分区：
文献类型：
--
作者：
Lu Y;Nyunt MS;Gwee X;Feng L;Feng L;Kua EH;Kumar R;Ng TP
研究生活事件压力是否与老年慢性阻塞性肺疾病（COPD）患者更大的心理困扰和较差的生活质量有关，与没有COPD的老年人相比。横断面研究。以人群为基础的样本（N=497）为65岁及以上COPD患者（支气管扩张后FEV1/FVC<0.70， N=136）和非COPD患者（N=277）。我们测量了有和没有COPD的参与者的生活事件压力、抑郁症状（GDS，老年抑郁量表）、认知症状和功能（CFQ，认知失败问卷和MMSE，迷你精神状态检查）以及身心健康功能状态（SF36-PCS，身体健康成分摘要和SF36-MCS，心理健康成分摘要）。在控制潜在混杂因素的双向方差分析中，生活事件压力与较差的GDS （p<0.001）、SF36-PCS （p=0.008）和SF36-MCS评分（p<0.001）的显著主效应相关，并且与COPD参与者的GDS评分（p<0.001）、SF36-PCS （p=0.045）和SF36-MCS （p=0.034）的显著交互效应相关，高于非COPD参与者。COPD的主要影响是支气管扩张剂后FEV1 （p<0.001）和认知症状（p=0.02）。我们的研究结果表明，生活事件压力与COPD患者更多的抑郁症状和更差的生活质量相关，远高于非COPD患者。进一步的研究应探讨压力认知评价、应对资源和社会心理支持在这一关系中的作用。
To investigate whether life event stress was associated with greater psychological distress and poorer quality of life in older individuals with chronic obstructive pulmonary disease (COPD), in comparison with their counterparts without COPD. Cross-sectional study. A population-based sample (N=497) of individuals aged 65 and above with COPD (postbronchodilatation FEV1/FVC<0.70, N=136) and without COPD (N=277). We measured life event stress, depressive symptoms (GDS, Geriatric Depression Scale), cognitive symptoms and function (CFQ, Cognitive Failures Questionnaire and MMSE, Mini-Mental State Examination), and physical and mental health functional status (SF36-PCS, Physical Health Component Summary and SF36-MCS, Mental Health Component Summary) in participants with and without COPD. In two-way analysis of variance controlling for potential confounders, life event stress was associated with significant main effects of worse GDS (p<0.001), SF36-PCS (p=0.008) and SF36-MCS scores (p<0.001), and with significant interaction effects on GDS score (p<0.001), SF36-PCS (p=0.045) and SF36-MCS (p=0.034) in participants with COPD, more than in non-COPD participants. The main effect of COPD was found for postbronchodilator FEV1 (p<0.001) and cognitive symptoms (p=0.02). Our findings indicate that life event stress was associated with more depressive symptoms and worse quality of life in individuals with COPD, much more than in those without COPD. Further studies should explore the role of cognitive appraisal of stress, coping resources and psycho-social support in this relationship.
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影响因子：
120.7
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Jemal, A;Ward, E;Thun, M
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