Thermogenic Adipose Redox Mechanisms: Potential Targets for Metabolic Disease Therapies.
Thermogenic Adipose Redox Mechanisms: Potential Targets for Metabolic Disease Therapies.
复制标题
热脂肪氧化还原机制：代谢疾病疗法的潜在靶标。
DOI：
10.3390/antiox12010196
复制
发表时间：
2023-01-14
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
糖尿病和非酒精性脂肪肝（NAFLD）等代谢性疾病会对受影响的人类产生多种负面健康后果。能量代谢失调是这些疾病的病理生理学基础的关键组成部分。脂肪组织是能量稳态的基本调节器，其利用几种氧化还原反应来进行代谢。特别是棕色和米色脂肪组织，在非颤抖产热过程中进行高度氧化反应，以热量形式耗散能量。能量代谢的适当调节需要协调的抗氧化机制来平衡氧化反应。事实上，非颤抖性产热激活可以引起氧化剂和抗氧化剂浓度的显著变化，以适应各种氧化环境。目前代谢疾病的治疗选择要么从啮齿动物模型转化为人类效果不佳（部分原因是创建生理相关啮齿动物模型的挑战），要么往往具有许多副作用，需要新的治疗方法。由于增加的棕色脂肪组织活性导致能量消耗增加，并且与对代谢健康的有益作用相关，例如减少肥胖，因此其作为代谢疾病的调节剂引起了极大的兴趣。有益健康效果的一个潜在原因可能是，尽管非颤抖性产热是非常氧化的，但它也与激活后氧化剂形成减少有关。然而，靶向其氧化还原机制，特别是改变代谢疾病仍然是一个探索不足的领域。因此，本文将讨论脂肪组织在能量平衡，非颤抖性产热在成人中的作用，氧化还原机制，可能作为新的治疗代谢性疾病的目标。
Metabolic diseases, such as diabetes and non-alcoholic fatty liver disease (NAFLD), have several negative health outcomes on affected humans. Dysregulated energy metabolism is a key component underlying the pathophysiology of these conditions. Adipose tissue is a fundamental regulator of energy homeostasis that utilizes several redox reactions to carry out the metabolism. Brown and beige adipose tissues, in particular, perform highly oxidative reactions during non-shivering thermogenesis to dissipate energy as heat. The appropriate regulation of energy metabolism then requires coordinated antioxidant mechanisms to counterbalance the oxidation reactions. Indeed, non-shivering thermogenesis activation can cause striking changes in concentrations of both oxidants and antioxidants in order to adapt to various oxidative environments. Current therapeutic options for metabolic diseases either translate poorly from rodent models to humans (in part due to the challenges of creating a physiologically relevant rodent model) or tend to have numerous side effects, necessitating novel therapies. As increased brown adipose tissue activity results in enhanced energy expenditure and is associated with beneficial effects on metabolic health, such as decreased obesity, it has gathered great interest as a modulator of metabolic disease. One potential reason for the beneficial health effects may be that although non-shivering thermogenesis is enormously oxidative, it is also associated with decreased oxidant formation after its activation. However, targeting its redox mechanisms specifically to alter metabolic disease remains an underexplored area. Therefore, this review will discuss the role of adipose tissue in energy homeostasis, non-shivering thermogenesis in adults, and redox mechanisms that may serve as novel therapeutic targets of metabolic disease.
登录
查看更多内容
影响因子：
4.2
作者：
Cohen DE;Fisher EA
通讯作者：
Fisher EA
DOI：
10.1080/13510002.2017.1324381
发表时间：
2018-12
期刊：
Redox report : communications in free radical research
影响因子：
--
作者：
Choi SW;Ho CK
通讯作者：
Ho CK
影响因子：
5.2
作者：
Collins S
通讯作者：
Collins S
DOI：
10.3390/antiox10071090
发表时间：
2021-07-07
期刊：
Antioxidants (Basel, Switzerland)
影响因子：
--
作者：
Abou-Rjeileh U;Contreras GA
通讯作者：
Contreras GA
影响因子：
20.1
作者：
Cheng, HJ;Zhang, ZS;Cheng, CP
通讯作者：
Cheng, CP