Antioxidant properties of drugs used in Type 2 diabetes management: could they contribute to, confound or conceal effects of antioxidant therapy?
Antioxidant properties of drugs used in Type 2 diabetes management: could they contribute to, confound or conceal effects of antioxidant therapy?
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DOI：
10.1080/13510002.2017.1324381
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发表时间：
2018-12
期刊：
影响因子：
--
通讯作者：
Ho CK
中科院分区：
文献类型：
--
作者：
Choi SW;Ho CK
目的：这是一篇叙述性综述，研究用于糖尿病治疗的药物的抗氧化特性，并讨论这些抗氧化作用是否有助于、混淆或掩盖抗氧化治疗的作用。方法：使用Web of Science、PubMed和Ovid系统地检索关于治疗人类或动物糖尿病的药物抗氧化作用的试验或观察性研究的文章。提取数据，包括许多受试者的数据、接受的治疗类型（和持续时间）以及主要和次要结局。主要结局报告了抗氧化剂浓度生物标志物的变化，次要结局报告了氧化应激生物标志物的变化。结果：糖尿病是一种以氧化应激升高为特征的疾病。它通常伴有一系列其他代谢紊乱，包括血脂升高、尿酸升高、高血压、内皮功能障碍和中心性肥胖。这篇综述表明，一些治疗糖尿病的药物通过清除自由基和上调抗氧化基因表达等机制具有体内和体外抗氧化特性。结论：用于治疗2型糖尿病的药物具有抗氧化作用。
Objectives: This is a narrative review, investigating the antioxidant properties of drugs used in the management of diabetes, and discusses whether these antioxidant effects contribute to, confound, or conceal the effects of antioxidant therapy. Methods: A systematic search for articles reporting trials, or observational studies on the antioxidant effect of drugs used in the treatment of diabetes in humans or animals was performed using Web of Science, PubMed, and Ovid. Data were extracted, including data on a number of subjects, type of treatment (and duration) received, and primary and secondary outcomes. The primary outcomes were reporting on changes in biomarkers of antioxidants concentrations and secondary outcomes were reporting on changes in biomarkers of oxidative stress. Results: Diabetes Mellitus is a disease characterized by increased oxidative stress. It is often accompanied by a spectrum of other metabolic disturbances, including elevated plasma lipids, elevated uric acid, hypertension, endothelial dysfunction, and central obesity. This review shows evidence that some of the drugs in diabetes management have both in vivo and in vitro antioxidant properties through mechanisms such as scavenging free radicals and upregulating antioxidant gene expression. Conclusion: Pharmaceutical agents used in the treatment of type 2 diabetes has been shown to exert an antioxidant effect..
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影响因子：
3.2
作者：
Bank, Alan J.;Kelly, Aaron S.;Gonzalez-Campoy, J. Michael
通讯作者：
Gonzalez-Campoy, J. Michael
影响因子：
5.1
作者：
Chakraborty, Arpita;Chowdhury, Subhankar;Bhattacharyya, Maitree
通讯作者：
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DOI：
10.1152/ajpheart.00403.2003
发表时间：
2003-12-01
影响因子：
4.8
作者：
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通讯作者：
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影响因子：
2.9
作者：
Bergman, Ebba;Matsson, Elin M.;Lennernas, Hans
通讯作者：
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影响因子：
10.4
作者：
Ali, F.;Hamdulay, S. S.;Mason, J. C.
通讯作者：
Mason, J. C.